Words similar to mek

Example sentences for: mek

How can you use “mek” in a sentence? Here are some example sentences to help you improve your vocabulary:

Although the alternative mechanism whereby the MEK1/ERK pathway regulates cPLA 2 is not known, it is possible that it affects membrane properties and/or cPLA 2 conformation that promotes optimal hydrolytic activity.
To better understand the regulation of cPLA 2 by the MEK1/ERK pathway and Ca 2+, we investigated the effect of MEK inhibitors on AA release, cPLA 2 phosphorylation of Ser 505, cPLA 2 translocation kinetics, and [Ca 2+] i increase in Madin-Darby canine kidney (MDCK) cells.
Treatment of MDCK cells with 30 μM PD098059, a less potent inhibitor of MEK [ 28 29 ] , resulted in a ~50% reduction in AA release in response to 100 μM ATP, 1 μM IONO, and 10 μM IONO (data not shown).
This finding is supported by the observation that activation of p21/Ras and MAPK ERK1/2 induced by TGFβ 1 is only reverted to the control level by the combination of the TGFβ-RII blocking antibody and the α V β 6 -blocking antibodies, or by inhibition of MEK1.
PD098059, an inhibitor of MEK activation, was included in all experiments, except the ERK activation experiments, to increase the specificity of the phospho-JNK antibody which recognizes the 44 and 42 kDa ERK bands as well as bands at 54 and 46 kDa.