Words similar to mek

Example sentences for: mek

How can you use “mek” in a sentence? Here are some example sentences to help you improve your vocabulary:

Protein kinase pathways play major roles in cPLA 2 activation, and regulation by the mitogen-activated protein kinase kinase (MEK) /extracellular-signal regulated kinase (ERK) signaling pathway has received particular attention.
This finding is supported by the observation that activation of p21/Ras and MAPK ERK1/2 induced by TGFβ 1 is only reverted to the control level by the combination of the TGFβ-RII blocking antibody and the α V β 6 -blocking antibodies, or by inhibition of MEK1.
The MAPK acts by stimulating AP-1 and a subsequent physical and functional interaction of AP-1 with NF-κB, resulting in a complex that synergistically transactivates the HIV-1 [ 60 ] . At the level of infection and entry, the activation of MAPK through the Ras/Raf/MEK (MAPK kinase) signaling pathway enhances the infectivity of HIV-1 virions.
Remarkably, preincubation with the MEK1 inhibitor PD98059 resulted in a reduced cytoskeletal immobilization and tyrosine phosphorylation of cellular proteins in response to stimulation with mature TGFβ 1 . This finding is in agreement with other observations that MEK1-mediated signal transduction is involved in cytoskeletal remodeling and integrin engagement [ 70 71 ] .
PD098059, an inhibitor of MEK activation, was included in all experiments, except the ERK activation experiments, to increase the specificity of the phospho-JNK antibody which recognizes the 44 and 42 kDa ERK bands as well as bands at 54 and 46 kDa.