Example sentences for: mek

How can you use “mek” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Thus, unlike the quantitative effect of U0126 on ERK activation, inhibition of MEK1 with U0126 only partially reversed the gel shift of cPLA 2 . The reversal of the gel shift was similar in cells treated with ATP and 1 and 10 μM IONO.

  • Treatment of MDCK cells with 30 μM PD098059, a less potent inhibitor of MEK [ 28 29 ] , resulted in a ~50% reduction in AA release in response to 100 μM ATP, 1 μM IONO, and 10 μM IONO (data not shown).

  • The MEK1/ERK pathway regulates cPLA 2 and ERKs phosphorylate cPLA 2 on Ser 505.

  • Remarkably, preincubation with the MEK1 inhibitor PD98059 resulted in a reduced cytoskeletal immobilization and tyrosine phosphorylation of cellular proteins in response to stimulation with mature TGFβ 1 . This finding is in agreement with other observations that MEK1-mediated signal transduction is involved in cytoskeletal remodeling and integrin engagement [ 70 71 ] .

  • ANOVA = analysis of variance; Erk= extracellular signal-regulated kinase; IC 50 = half-maximal inhibition; IRS = insulin receptor substrate; LDH = lactate dehydrogenase; MAPK = mitogen-activated protein kinase; MEK = MAPK/extracellular signal-regulated kinase kinase; mTOR = mammalian target of rapamycin; PBS = phosphate-buffered saline; PI 3-kinase = phosphatidylinositol 3-kinase; RDS = respiratory distress syndrome; SD = standard deviation of the mean; SE = standard error of the mean; SP = surfactant protein; TPA = 12-


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