Example sentences for: mek

How can you use “mek” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • MEK's primary role is activation of MAP kinase through threonine and tyrosine phosphorylation of MAP kinase which in turn phosphorylates and regulates the function of several nuclear proteins, such as transcription factors, as well as cytosolic and membrane-associated proteins, such as the insulin and EGF receptors.

  • However, MEK inhibition only partially affected cPLA 2 phosphorylation and had no effect on the kinetics of Ca 2+-mediated cPLA 2 translocation to membrane.

  • We found that inhibition of MEK1 by U0126 significantly inhibited AA release and this was correlated with inhibition of ERK activation.

  • cPLA 2 translocates primarily to Golgi in response to a transient [Ca 2+] i changes and to Golgi and ER in response to a sustained [Ca 2+] i increase [ 15 ] . The reduction in AA release by MEK inhibition did not involve a failure in [Ca 2+] i release or translocation.

  • This approach has been successful in producing conditional forms of the Tec family PTK Bmx [ 22], and also the PTKs v-Src [ 23], Hck [ 24] and Abl [ 25], the serine/threonine kinases Raf [ 26] and Akt [ 27], and the dual specificity protein kinase MEK1 [ 23].


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