Words similar to meiotic
Example sentences for: meiotic
How can you use “meiotic” in a sentence? Here are some example sentences to help you improve your vocabulary:
The H2-Eb1 gene contains a recombination hotspot, which has a predominant role in generating different recombinants through meiotic crossing-over within the I region of the mouse major histocompatibility complex (MHC) [ 24].
The value obtained in the rec12 mutants was 2.5-fold higher than the predicted random value, indicating that the segregation errors are not simply the consequence of random chromosome assortment (nondisjunction) occurring exclusively during one of the two meiotic divisions.
A meiotic checkpoint could provide additional time for missegregating chromosomes to correct their erroneous wanderings during MI [ 10 ] . We propose two likely mechanisms by which the Rec12 protein improves the MI segregation of achiasmatic chromosomes.
Precocious separation of sister chromatids during MI [ 44 46 ] can also produce diploid meiotic products, 67% of which would be heterozygous for centromere markers (Figure 5D) [ 38 ] . However, the average heterozygosities in the rec12-117 and rec12-D15 mutants were significantly below this value, indicating that these mutants must have suffered some proportion of MII segregation errors.
The rec12-117 mutant was isolated in a genetic screen; the rec12-117 mutation reportedly confers a 100-fold or greater reduction of intragenic recombination and a 6-fold reduction of intergenic recombination [ 33 ] . To define more precisely the requirement for Rec12 in meiotic chromosome dynamics, we used gene replacement to generate a null ( rec12-D15 ) mutation and a mutation in the putative active site tyrosine ( rec12-Y98F ). We then determined the effects of these mutations upon intergenic (crossover) recombination within intervals of chromosomes
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