Words similar to mda-mb-
Example sentences for: mda-mb-
How can you use “mda-mb-” in a sentence? Here are some example sentences to help you improve your vocabulary:
We have previously characterized an experimental system that enables comparative molecular screening and functional evaluation of candidate breast metastasis-related genes in an isogenic background [ 2 ] . Two independent clones of opposing metastatic phenotype were derived from the MDA-MB-435 breast tumor cell line (metasatic M-4A4 and nonmetastatic NM-2C5 cell lines).
In order to test whether TGFβ 1 signaling via α V β 6 is specific for SMAD4 deleted BxPC-3 cells or if this is a general phenomenon, we investigated signaling in TGFβ 1 -sensitive carcinoma cell lines HeLa, MCF-7 and MDA-MB-231.
The effect of TSP-1 expression on tumor growth and metastasis has been examined in vivo by orthotopic inoculation of TSP-1-overexpressing MDA-MB-435 cells.
Transient transfection of MDA-MB-231 breast cancer cells has been described previously [ 19 ] . Briefly, 2 μg 3TP-Luc together with 0.3 μg β-galactosidase expression plasmid were transfected into cells grown to 70-80% confluency in 6-well plates using LipofectAMINE reagent (Invitrogen) following the manufacturers protocol.
TGFβ has been shown also to stabilize the mRNA of the smad7 gene [ 25 ] , while stabilization of RNA does not play a major role in regulation of the pthrp gene in MDA-MB-231 cells [ 19 ] . In addition, SB-203580 also inhibits p38 activity which has been shown to play a role in TGFβ signalling [ 36 37 38 39 40 41 ] . Hence, several factors could be responsible for the differential sensitivity of TGFβ-responsive genes to SB-203580.
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