Words similar to lxrα
Example sentences for: lxrα
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[ 34 ] found AA to be more potent than DHA (saturated and monounsaturated being ineffective) at inhibiting activation of SREBP-1c promoter and LXRE enhancer constructs, induced by co-expression of LXRα or -β.
One mechanism is to antagonize activation of the LXR receptor leading to fewer LXR/RXR heterodimer complexes to bind the LXRE in the SREBP-1c promoter and less SREBP-1c-mediated transcription of SRE-containing genes [ 34 ] . The PPARα signaling cascade intertwines with SREBP pathways since LC-PUFA also activate PPARα, which can induce LXRα expression [ 17 ] .
Until recently, LC-PUFA effects on gene transcription were thought primarily to be mediated by a single subfamily of orphan nuclear receptors - peroxisome proliferator activated receptors (PPARs); however, it is now becoming evident that FAs can affect many different genes either via direct interactions or indirectly through additional transcription factors including hepatic nuclear-4α (HNF-4α), nuclear factor κβ (NF-κβ), retinoid X receptor α (RXRα), sterol regulatory element binding protein-1c (SREBP-1c), and liver X receptors (LXRα and LXRβ) [ 17 ] . Indeed, the enthusiasm for uncovering the biological pathways underlying the beneficial actions of LC-PUFA has revealed a story that is increasingly more complex than originally supposed [ 23 ] , thereby making microarray technology an ideal platform to further decipher the many roles of these nutritional lipids.
Several members of the ATP-binding cassette (ABC) superfamily, such as Abca1, are induced via PPARγ and LXRα activation [ 63 ] . Abca1 has been shown to play a role in reverse cholesterol pathways and may be linked to HDL deficiency in metabolic syndromes [ 64 ] . In macrophages, 18:2n6 and AA increased ABCA1 protein degradation without affecting transcriptional levels [ 65 ] . In the current study, Abca1 was significantly decreased by FUNG and FISH.
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