Words similar to lxxll
Example sentences for: lxxll
How can you use “lxxll” in a sentence? Here are some example sentences to help you improve your vocabulary:
Thus, some of the observed ERβ specificity is probably a consequence of an unexpected ability to tolerate the absence of a leucine residue at the N-terminus of the LXXLL motif.
A mutation (PL T IRML>PL L IRML) that restores the LXXLL consensus increases ERβ binding to N-CoR and permits ERα to bind to N-CoR in the presence of estrogens in mammalian two-hybrid assays.
The unliganded LBD recognizes hydrophobic motifs, termed interaction domains (IDs), which are reiterated three times in N-CoR and twice in SMRT and conform to the consensus L/IXXIIXXXL [ 4 ] (see also [ 16 ] ). By contrast, the liganded LBD binds shorter hydrophobic motifs termed NR boxes that are reiterated several times within each coactivator and conform to the consensus LXXLL.
This sequence does not exactly conform to the LXXLL consensus, but contains features (underlined) that resemble the ERβ H12 region (L L LE ML ), and artificial ERβ interacting LXXLL peptides (293, P NLIS LLS ; D47, PL LLS LLS ), both of which bind to the ERβ AF-2 surface [ 43 44 45 46 47 ] . Moreover, the presence of a proline residue amino-terminal to the hydrophobic groups is typical of so-called class II LXXLL motifs which are found in ERβ interacting cofactors such as TRAP220 and RIP140 [ 45 ] . Finally, the unusual C-terminal hydrophobic pair (ML) has been observed in ERα and ERβ H12 [ 43 44 48 ] , and in RIP140 NR boxes [ 19 ] .
Phage display techniques have revealed that ERα and ERβ show different preferences in LXXLL binding (reviewed in [ 34 35 ] ). Moreover, some cofactors that contain LXXLL motifs show differential binding to LBDs of the ER isoforms (reviewed in [ 36 ] ). SHP binds ERα preferentially [ 37 ] , and represses ERα activity more strongly than that of ERβ.
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