Words similar to lxxll
Example sentences for: lxxll
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Intriguingly, the β-box contains N-terminal proline and C-terminal serine residues that extend the homology of this region to an artificial ERβ-specific peptide [ 45 ] . However, the β-box also lacks the first Leu of the consensus LXXLL.
A mutation (PL T IRML>PL L IRML) that restores the LXXLL consensus increases ERβ binding to N-CoR and permits ERα to bind to N-CoR in the presence of estrogens in mammalian two-hybrid assays.
Phage display techniques have revealed that ERα and ERβ show different preferences in LXXLL binding (reviewed in [ 34 35 ] ). Moreover, some cofactors that contain LXXLL motifs show differential binding to LBDs of the ER isoforms (reviewed in [ 36 ] ). SHP binds ERα preferentially [ 37 ] , and represses ERα activity more strongly than that of ERβ.
Stat3 also contains in its N-terminus one of this motifs ( 221LAGLL 225) [ 39 ] . Moreover, Stat3 also presents a Ser at -2 position of the LXXLL sequence, which in the case of the coactivator TRBP defines selectivity for nuclear receptors [ 40 ] . Phosphorylation of Stat3 has been reported to occur only in 705Tyr and in 727Ser, allowing dimerization and full transactivating activity [ 41 ] . Whether this 219Ser next to the LXXLL motif is involved in the coactivator activity of Stat3, and the interaction of Stat3 with other coactivators only takes place in the context of Stat3 transcription factor activity or also can be part of the general mechanism of the transcription complex formation requires further studies.
Mutation of N-CoR to obtain a β-box sequence that more closely resembled a conventional LXXLL motif (T2402L) led to enhanced hormone-dependent interactions with ERβ and permitted novel hormone-dependent interactions with ERα (Fig.
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