Example sentences for: lxxll

How can you use “lxxll” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The unliganded LBD recognizes hydrophobic motifs, termed interaction domains (IDs), which are reiterated three times in N-CoR and twice in SMRT and conform to the consensus L/IXXIIXXXL [ 4 ] (see also [ 16 ] ). By contrast, the liganded LBD binds shorter hydrophobic motifs termed NR boxes that are reiterated several times within each coactivator and conform to the consensus LXXLL.

  • Structure-function analysis of the NCoAs have revealed multiple copies of a signature motif, LXXLL, with conserved spacing that is required for interaction with nuclear receptors and CBP/p300 [ 99 101 ] . Intriguingly, different LXXLL motifs are required for PPARγ (Peroxisome Proliferator activated receptor γ, a gene down-regulated in Tat expressing cells; Acc# L07592, Table 1) function in response to different classes of ligands, suggesting distinct configuration of assembled complexes.

  • A mutation (PL T IRML>PL L IRML) that restores the LXXLL consensus increases ERβ binding to N-CoR and permits ERα to bind to N-CoR in the presence of estrogens in mammalian two-hybrid assays.

  • Mutation of N-CoR to obtain a β-box sequence that more closely resembled a conventional LXXLL motif (T2402L) led to enhanced hormone-dependent interactions with ERβ and permitted novel hormone-dependent interactions with ERα (Fig.

  • Thus, some of the observed ERβ specificity is probably a consequence of an unexpected ability to tolerate the absence of a leucine residue at the N-terminus of the LXXLL motif.


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