Words similar to lxxll

Example sentences for: lxxll

How can you use “lxxll” in a sentence? Here are some example sentences to help you improve your vocabulary:

Thus, some of the observed ERβ specificity is probably a consequence of an unexpected ability to tolerate the absence of a leucine residue at the N-terminus of the LXXLL motif.
A mutation (PL T IRML>PL L IRML) that restores the LXXLL consensus increases ERβ binding to N-CoR and permits ERα to bind to N-CoR in the presence of estrogens in mammalian two-hybrid assays.
Mutation of N-CoR to obtain a β-box sequence that more closely resembled a conventional LXXLL motif (T2402L) led to enhanced hormone-dependent interactions with ERβ and permitted novel hormone-dependent interactions with ERα (Fig.
Thus, the unusual sequence of the β-box contributes to ERβ specificity and ERβ can tolerate the absence of a conserved N-terminal leucine in LXXLL motifs.
Structure-function analysis of the NCoAs have revealed multiple copies of a signature motif, LXXLL, with conserved spacing that is required for interaction with nuclear receptors and CBP/p300 [ 99 101 ] . Intriguingly, different LXXLL motifs are required for PPARγ (Peroxisome Proliferator activated receptor γ, a gene down-regulated in Tat expressing cells; Acc# L07592, Table 1) function in response to different classes of ligands, suggesting distinct configuration of assembled complexes.