Words similar to lxr

Example sentences for: lxr

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One mechanism is to antagonize activation of the LXR receptor leading to fewer LXR/RXR heterodimer complexes to bind the LXRE in the SREBP-1c promoter and less SREBP-1c-mediated transcription of SRE-containing genes [ 34 ] . The PPARα signaling cascade intertwines with SREBP pathways since LC-PUFA also activate PPARα, which can induce LXRα expression [ 17 ] .
These compounds can activate some nuclear receptors including steroidogenic factor 1 [ 44 ] and LXR, which may be partially responsible for their biological activities [ 45 46 ] . Cholesterol oxides are inhibitors of HMG-CoA reductase, the key enzyme of cholesterol biosynthesis pathway [ 47 ] . The ability to bind to an intracellular receptor, oxysterol binding protein, may be responsible for their inhibition of cholesterol biosynthesis [ 48 49 ] . It should be noted that addition of cholesterol does not prevent cholesterol oxide induced cell death, which leads to the suggestion that inhibition of cholesterol synthesis is not the cause of cholesterol oxide induced PCD [ 50 51 ] . The critical events that result in cholesterol oxide induced cytotoxicity remain to be determined.
LXR liver X receptor
LXRE LXR responsive elements
Within the SREBP promoter element, the liver X receptor (LXR)-responsive elements (LXRE) may have an important role [ 34 ] . LC-PUFA may affect SREBP-1c mediated transcription via several mechanisms.