Words similar to lipodystrophy
Example sentences for: lipodystrophy
How can you use “lipodystrophy” in a sentence? Here are some example sentences to help you improve your vocabulary:
Potential mechanisms for altered adipocyte function include, direct binding to PPARgamma or inhibition of transcription of PPARgamma promoter [ 37 ] . The lipodystrophy syndrome may be a result of the inhibition of 2 proteins involved in lipid metabolism that have significant homology to the catalytic site of HIV proteases; namely cytoplasmic retinoic acid binding protein type 1 and low density lipoprotein-receptor-related protein [ 38 ] . An additional mechanism of PPAR down-regulation may be related to Tat expression in latent cells.
In addition to DCM with conduction system disease and variable skeletal muscle involvement, mutations in the Lamin A/C gene [OMIM 150330] have been shown to cause autosomal dominant [ 11 ] and autosomal recessive [ 12 ] Emery-Dreifuss Muscular Dystrophy (EDMD), autosomal dominant limb-girdle muscular dystrophy type 1B (LGMD) [ 13 ] , autosomal recessive type 2 Charcot-Marie Tooth type 2 [ 14 ] , familial partial lipodystrophy [ 15 16 ] , Mandibuloacral dysplasia [ 17 ] and Hutchinson-Gilford progeria [ 18 ] . The phenotypic spectrum from DCM to EDMD and limb girdle muscular dystrophy appears continuous.
Finally, patients with AIDS who are receiving therapy with HIV-1 protease inhibitors have been reported to be afflicted with a syndrome characterized by lipodystrophy (fat redistribution favoring the accumulation of abdominal and cervical adipose tissue), hyperlipidemia, and insulin resistance.
No differences between the APV600/RTV and APV1200 treatment arms were observed regarding the frequency of drug-related grade 1-4 adverse events (44% vs 45%), frequency of discontinuing treatment due to adverse events (7% vs 8%), incidence of hyperglycemia (1 vs 0 patient), nonspecific lipodystrophy (1 vs 0), buffalo hump (1 vs 0), or hypercholesterolemia (1 vs 0).
Amprenavir (APV) is a potent protease inhibitor (PI) that is used in combination with other antiretroviral drugs for the treatment of antiretroviral-naïve and -experienced adults and children with HIV infection [ 1 2 3 4 5 ] . APV offers the convenience of twice-daily (BID) administration with no food or fluid restrictions [ 6 7 ] . Preclinical and clinical data suggest that APV has a lower potential to cause lipodystrophy and metabolic abnormalities than other currently available PIs [ 8 9 10 ] . APV has a distinct resistance profile that permits it to be considered as a treatment option for either PI-naïve or PI-experienced patients [ 11 ] . In a 64-week trial in treatment-naïve patients (NZTA4002; n = 302), APV 1200 mg, administered BID (APV1200) with one abacavir 300 mg tablet and one lamivudine 150 mg/zidovudine 300 mg combination tablet (Combivir ®), was as effective as nelfinavir 750 mg three times daily plus Combivir BID, with regard to the proportion of patients achieving HIV-1 RNA <40 copies/mL at week 64: 77% vs 66% (as-treated analysis) [ 12 ] . However, many patients in this trial withdrew prematurely because of adverse events that may have been, in part, related to the high pill burden (16 large 150 mg soft-gelatin capsules daily) associated with APV dosing and excipients contained in the APV formulation available at the time of the trial.
Loading...