Example sentences for: lipoate-binding

How can you use “lipoate-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Visual examination of the structure of this insert domain revealed a topology with elements of both a sandwich and a barrel, and two "waist"-like structures that are characteristic of the sandwich-barrel hybrid motif (SBHM) fold [ 75 76 ] (see also the SCOP database [ 65 ] ). The SBHM fold is present in biotin/lipoate carrier domains and their homologs found in a variety of enzymes and transporters [ 76 ] . A DALI search with this insert domain from the β subunit of Thermus DDRP showed similarity to the SBHMs from various biotin/lipoate-binding enzymes, such as acetyl-CoA carboxylase (1bdo) or dihydrolipoamide acetyltransferase (1iyu) with Z scores of ~6 and RMSD ~2.

  • The wide spread in different phylogenetic lineages of two other SBHM domains, namely those found in dihydrolipoamide acetyltransferase and the glycine-cleaving enzyme, is indicative of their presence in LUCA [ 76 ] . The SBHM of the DDRPs is specifically related to the biotin/lipoate-binding SBHMs.

  • The two share a conserved basic residue that is present immediately prior to strand 4. In all biotin/lipoate-binding SBHMs, this position is occupied by a lysine, which covalently binds organic radical ligands (Fig.


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