Words similar to lcn
Example sentences for: lcn
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Mann-Whitney U test comparison of SU5416 and control results from both analyses indicates that three of the six genes displayed statistical significance (p-values less than 0.05) based on the SYBR Green RT-PCR data (Table 3); these are CD24, lactoferrin, and LCN2.
When the cases were pooled (n = 67) and subjected to classification prediction, the overall accuracy of assignment to the appropriate trial arm was 84% when lactoferrin, CD24, and LCN2 were used as the predictor gene set (inclusion of MMP-9 slightly reduced the accuracy of cross-validation).
However, it is worth noting that we have retrospectively applied Significance Analysis of Microarrays, or SAM, [ 27 ] to the Affymetrix dataset: 3 of the 10 most significant genes identified by that method were among the 4 that were verified by RT-PCR (LCN2, CD24, and lactoferrin), with MMP-9 ranked sixteenth.
The mouse homologue of one of the candidate biomarkers, LNC2, has been shown to be regulated at the transcriptional level by dexamethasone in murine cells [ 22 ] . However, there is no published evidence that the human LCN2 gene is likewise dexamethasone-inducible, and there is no description of glucocorticoid-responsive elements in the 5' regulatory region of the human LCN2 gene [ 28 ] . Further, preliminary investigation in our laboratory, using in vitro cultures of purified PBMCs from healthy volunteers, indicates that neither the LCN2 gene nor any of the other 3 transcripts is directly inducible by acute treatment with either SU5416 or dexamethasone (data not shown).
Also noteworthy is a report describing bovine lactoferrin as an inhibitor of VEGF-mediated angiogenesis in a rat model [ 29 ] . Intriguingly, a recent report has identified a high molecular weight urinary MMP to be a complex of MMP-9 and LCN2 (herein referred to as neutrophil gelatinase-associated lipocalin, or NGAL) proteins [ 30 ] . Such urinary MMP complexes have been described as useful markers for cancer diagnosis and prognosis.
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