Words similar to lcn
Example sentences for: lcn
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Mann-Whitney U test comparison of SU5416 and control results from both analyses indicates that three of the six genes displayed statistical significance (p-values less than 0.05) based on the SYBR Green RT-PCR data (Table 3); these are CD24, lactoferrin, and LCN2.
The mouse homologue of one of the candidate biomarkers, LNC2, has been shown to be regulated at the transcriptional level by dexamethasone in murine cells [ 22 ] . However, there is no published evidence that the human LCN2 gene is likewise dexamethasone-inducible, and there is no description of glucocorticoid-responsive elements in the 5' regulatory region of the human LCN2 gene [ 28 ] . Further, preliminary investigation in our laboratory, using in vitro cultures of purified PBMCs from healthy volunteers, indicates that neither the LCN2 gene nor any of the other 3 transcripts is directly inducible by acute treatment with either SU5416 or dexamethasone (data not shown).
A set of 4 transcripts (CD24, lactoferrin, LCN2, and MMP-9) was identified, whose expression was significantly induced at the end of one treatment cycle relative to baseline following SU5416 administration.
Also noteworthy is a report describing bovine lactoferrin as an inhibitor of VEGF-mediated angiogenesis in a rat model [ 29 ] . Intriguingly, a recent report has identified a high molecular weight urinary MMP to be a complex of MMP-9 and LCN2 (herein referred to as neutrophil gelatinase-associated lipocalin, or NGAL) proteins [ 30 ] . Such urinary MMP complexes have been described as useful markers for cancer diagnosis and prognosis.
When the cases were pooled (n = 67) and subjected to classification prediction, the overall accuracy of assignment to the appropriate trial arm was 84% when lactoferrin, CD24, and LCN2 were used as the predictor gene set (inclusion of MMP-9 slightly reduced the accuracy of cross-validation).
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