Words similar to lcr
Example sentences for: lcr
How can you use “lcr” in a sentence? Here are some example sentences to help you improve your vocabulary:
LCR15s extend only ~15 kb individually, but are often present in clusters extending to 30-60 kb.
On the basis of the findings of Pujana et al ., the GLP/LCR15 duplicon is present at multiple regions of human genomic instability [ 21 ] . In addition, the GLP/LCR15 duplicon was shown by Gilles et al . to be polymorphic in the human population - showing that these sequences have considerable intraspecific plasticity [ 18 ] . The GLP/LCR15 duplication family has expanded over the last 20 million years of primate evolution, before the divergence of the great ape lineages, resulting in a multitude of copies (estimated at 27) present at multiple sites along chromosome 15, providing the conditions required for rearrangements driven by nonallelic homologous recombination (NAHR) [ 18 19 21 27 ] . We have begun an investigation of the organization of this region within the chimpanzee lineage.
The LCR is believed to mimic the response of Y. pestis in contact with eukaryotic cells when calcium ions are removed from the growth medium at 37°C.
Thus, in the three distinct lines studied, the CD2 promoter/LCR/enhancer directed the expression of the hCARΔcyt transgene to the T cell and in one of the lines, the B cell lineage.
The resulting fragment (hCARΔcyt) was restriction endonuclease digested and subcloned into the EcoRI/SmaI site of the VA human CD2 mini-gene containing the human CD2 promoter and 3' LCR [ 16 ] . Automated sequencing (Applied Biosystems, Foster City, CA; University of Alabama at Birmingham Department of Microbiology sequencing facility) of the entire construct confirmed its accuracy.
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