Words similar to lcr
Example sentences for: lcr
How can you use “lcr” in a sentence? Here are some example sentences to help you improve your vocabulary:
LCR15s extend only ~15 kb individually, but are often present in clusters extending to 30-60 kb.
3. This location contains duplicon-like sequences, based on BLAST-detected homology relationships to other non-overlapping BAC clones, which contain LCR15-inclusive sequences.
The resulting fragment (hCARΔcyt) was restriction endonuclease digested and subcloned into the EcoRI/SmaI site of the VA human CD2 mini-gene containing the human CD2 promoter and 3' LCR [ 16 ] . Automated sequencing (Applied Biosystems, Foster City, CA; University of Alabama at Birmingham Department of Microbiology sequencing facility) of the entire construct confirmed its accuracy.
This plasmid, called pCD1 [ 1 ] in Y. pestis , encodes for a type III secretion apparatus necessary for the translocation of effector proteins (Yops) into eukaryotic target cells [ 2 ] . The net result of this polarized toxin translocation is the disruption of eukaryotic cell signalling and structure [ 2 ] . Induction of the virulence-related genes on pCD1 is linked to an in vitro phenomenon termed the Low Calcium Response (LCR).
On the basis of the findings of Pujana et al ., the GLP/LCR15 duplicon is present at multiple regions of human genomic instability [ 21 ] . In addition, the GLP/LCR15 duplicon was shown by Gilles et al . to be polymorphic in the human population - showing that these sequences have considerable intraspecific plasticity [ 18 ] . The GLP/LCR15 duplication family has expanded over the last 20 million years of primate evolution, before the divergence of the great ape lineages, resulting in a multitude of copies (estimated at 27) present at multiple sites along chromosome 15, providing the conditions required for rearrangements driven by nonallelic homologous recombination (NAHR) [ 18 19 21 27 ] . We have begun an investigation of the organization of this region within the chimpanzee lineage.
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