Words similar to lcr
Example sentences for: lcr
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The second duplicon recognized within the 600 kb sub-interval was originally described as the Golgin-Linked-to-PML (promyelocytic leukemia) duplicon, or GLP duplicon, by Gilles et al . [ 18 ] and subsequently described as LCR15 by Pujana et al . [ 19 ] , Gratacos et al . [ 20 ] and Pujana et al.
On the basis of the findings of Pujana et al ., the GLP/LCR15 duplicon is present at multiple regions of human genomic instability [ 21 ] . In addition, the GLP/LCR15 duplicon was shown by Gilles et al . to be polymorphic in the human population - showing that these sequences have considerable intraspecific plasticity [ 18 ] . The GLP/LCR15 duplication family has expanded over the last 20 million years of primate evolution, before the divergence of the great ape lineages, resulting in a multitude of copies (estimated at 27) present at multiple sites along chromosome 15, providing the conditions required for rearrangements driven by nonallelic homologous recombination (NAHR) [ 18 19 21 27 ] . We have begun an investigation of the organization of this region within the chimpanzee lineage.
The result of this in vitro induction of virulence genes is the massive secretion of Yops into the growth medium, accompanied by a characteristic growth restriction that is a hallmark phenotype of the LCR [ 3 ] .
However, there is highly significant homology over ~100-kb of sequence from assembly contig NT_035325 mapping to 15q26, where LCR-15 duplicon sequences have been reported [ 18 ] . These sequences appear to correspond to the LCR15 class of duplicons, based on sequence content.
This plasmid, called pCD1 [ 1 ] in Y. pestis , encodes for a type III secretion apparatus necessary for the translocation of effector proteins (Yops) into eukaryotic target cells [ 2 ] . The net result of this polarized toxin translocation is the disruption of eukaryotic cell signalling and structure [ 2 ] . Induction of the virulence-related genes on pCD1 is linked to an in vitro phenomenon termed the Low Calcium Response (LCR).
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