Words similar to lctx
Example sentences for: lctx
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In the clinical management of individual patients affected with breast cancer, an increased α LCTX value may indicate the presence of bone metastases and will call for a closer clinical evaluation of the patient and/or initiation of preventive therapy (e.g.
In patients with breast cancer-induced bone metastases, the urinary excretion of the newly synthesised α LCTX form was more increased than the age-modified forms β Land α D. Compared with NC- patients, the HC+ patients had a 3.4-fold elevation in α LCTX and the NC+ patients had 2.2-fold higher levels of α LCTX ( P < 0.01).
The present data suggest that the levels of α LCTX are most affected by the altered bone turnover associated with metastatic invasion of bone.
α LCTX levels alone showed a significant elevation in 58% of the metastatic patients, which probably reflects an increased bone turnover (increased resorption + increased formation) as an important feature in the majority of bone metastatic patients.
When individual Z scores of CTX were calculated for the metastatic breast cancer patients compared with the non-metastatic patients, the α LCTX form and the α L/α DCTX ratio showed the highest average increases in accordance with the ability of the α LCTX levels and the α L/α DCTX ratio to most sensitively reflect alterations in the balance between the anabolic and catabolic processes of bone turnover (Fig.