Example sentences for: isotypes

How can you use “isotypes” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • There were no differences before and after arginine-Sepharose fractionation in the percentages of any of the β-tubulin isotypes tested in this study (data not shown).

  • To find out if the PG-specific IgG1 response is dependent on IL-4, we immunized IL-4-deficient mice with PG and measured the PG-specific IgG1 and IgG2a isotypes.

  • Negative controls were performed by omission of the primary antibody, and positive controls for tubulin isotypes were performed with pig brain tissues.

  • In ovarian cancer cells, mutations in residues near the putative paclitaxel-binding site of β-tubulin class I were found in paclitaxel-resistant ovarian cancer cells [ 23 ] . Other work suggests that changes in tubulin isotypes alone cannot confer resistance to antimitotics.

  • Their effectiveness in cancer chemotherapy is thought to be due to their ability to reduce the dynamics of microtubules in mitotic spindles, thus preventing spindle assembly and interrupting the normal movement of sister chromatids toward the spindle poles [ 3 4 5 6 7 8 9 ] . Tubulin, a 100 kDa αβ heterodimer, is structurally heterogeneous, with seven genes encoding α-tubulin and β-tubulin isotypes.


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