Example sentences for: isotypes

How can you use “isotypes” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • There are reports of tubulin isotypes that are differentially incorporated into microtubule structures [ 62 ] . However, it is not possible to fractionate microtubules from total cytoplasmic tubulin with quick-frozen human tissue samples.

  • These results suggested that β-tubulin classes II and I + IV are the predominant tubulin isotypes in these tissues.

  • Changing the interaction of peptide, MHC class II molecules, T cell receptors and other antigen-presenting cell specific ligand interactions to foster stronger, higher affinity T cell signalling has been shown in mice to skew T cell differentiation from Th2 to Th1-like patterns [ 40 41 42 43 44 45 46 47 48 49 50 ] . Differences in Th-differentiation patterns have downstream effects on the type of immune response mounted, and in particular on the isotypes of antibody expressed.

  • Negative controls were performed by omission of the primary antibody, and positive controls for tubulin isotypes were performed with pig brain tissues.

  • The expression of genes encoding α-tubulin and β-tubulin seems to be developmentally regulated [ 19 ] . For example, tubulin isotype expression patterns change during the development and maturation of neurons [ 14 20 ] . Studies with paclitaxel or other antimitotic agents, such as colchicine or estramustine, indicate that drug interactions with tubulin isotypes differ [ 21 22 23 24 25 ] and might contribute to cell resistance to antimitotics [ 26 27 28 29 30 31 ] . However, one group of antimitotic agents, the vinca alkaloids, was shown to bind with similar affinity to all tubulin isotypes [ 12 ] , suggesting that alterations in drug binding affinity is unlikely to be the cause of drug resistance.

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