Words similar to isotypes

Example sentences for: isotypes

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Phorbol esters are often used as activators of protein kinase C (PKC) to investigate the role of the kinase in cellular functions [ 1 ] . Pancreatic β-cells possess α, β1, δ and ε PKC isotypes [ 2 ] , and activation of PKC is known to synergize with glucose stimulation in insulin secretion [ 3 4 5 ] . PKC, via protein phosphorylation seems to facilitate exocytosis of insulin granules [ 6 7 8 ] . In glucose-stimulated insulin secretion, ATP-sensitive K +channels (K ATP (SUR1, Kir6.
Nevertheless, we cannot exclude the possibility that changes in the distribution of tubulin isotypes in normal and tumor breast tissue, in conjunction with other molecular factors, might still be relevant to disease progression and cellular response to antimitotic drugs.
In other work, β-tubulin classes III and IVa were shown to increase in paclitaxel-resistant prostate cancer cells [ 29 ] . However, these two isotypes continued to be expressed in the lowest amounts.
It was demonstrated that one group of antimitotic agents, vinca alkaloids, bind with similar affinity to all β-tubulin isotypes [ 12 ] , thus suggesting for therapy with vinorelbine, vinblas-tine, or vincristine that tubulin isotype levels are incidental for efficacy.
In vertebrates the concentrations of the specific isotypes vary in different tissues [ 11 17 ] , although the functional role for the variability in tubulin polypeptides is uncertain [ 17 18 ] .