Example sentences for: isotype-specific

How can you use “isotype-specific” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure isotype-specific antibodies in serial dilutions (1:1000 to 1:62,500) of sera.

  • This putative mechanism appears to be isotype-specific, since the protein levels of PP1δ and PP1γ1 remained relatively unchanged in response to induced expression of PP1α.

  • The major differences between isotype classes reside in the last 15-20 amino acids of the carboxy-termini [ 10 11 ] , and these differences have been exploited in the development of isotype-specific antibodies [ 12 13 14 ] . Mammalian microtubules are formed from a mixture of α-tubulin and β-tubulin isotype classes [ 11 15 16 ] , and the antimitotics used in chemotherapy interact primarily with β-tubulin.

  • Western blotting for additional isoforms of PP1 reveals that this reduction in PP1α following induction is isotype-specific; when 6His-HA-PP1α levels increase, concomitant with a decrease in PP1α levels, PP1δ and PP1γ1 levels remain relatively unchanged from those found in uninduced cell lysate (Figure 10).

  • PCR reactions were performed with isotype-specific primer pairs for β-tubulin isotype classes I, II, III, IVa, and IVb as described [ 46 ] , with minor modifications to correct mismatches and to match the melting temperatures more closely.


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