Example sentences for: isotype

How can you use “isotype” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • However, because our data show similar isotype amounts in normal and tumor breast tissues, differential tissue sampling seems not to be an issue in these experiments.

  • Furthermore, transfection of CHO cells with β-tubulin classes I, II, or IVb did not produce resistance to paclitaxel [ 32 ] . The alternative hypothesis, derived from the work of Cabral and colleagues, is that rather than the tubulin isotype levels, the amount of polymerized tubulin is the critical factor that regulates response to antimitotic drugs.

  • Determination of immunoglobulin isotype

  • Four residues in the vicinity of the ligands are varying from one receptor isotype to the other: Thr183 of alpha4 (Ser in alpha3 and alpha7), Ala135 of beta2 (Leu in beta4 and Val in alpha7), Phe144 of beta2 (Leu in beta4 and Gln in alpha7), and Thr83 of beta2 (Lys in beta4 and Gln in alpha7) (Figure 1).

  • Over the past decade paclitaxel and docetaxel have become important chemotherapeutic agents for both ovarian and breast cancers [ 1 2 ] . Considerable interest has focused on the target receptor - tubulin - and mechanisms underlying efficacy, toxicity, and drug resistance [ 7 8 23 24 27 28 ] . Whether tubulin isotype levels might determine cellular responses to antimitotic agents remains controversial.


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