Example sentences for: interrupting

How can you use “interrupting” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Our data showed that a BRCA1 mutation interrupting the RING domain altered apoptosis in ovarian surface epithelial cells.

  • Cumulatively, however, these observations do suggest a mechanism whereby HIV-1 expression in renal epithelium may induce cyclin D 1 : activation of Src-family kinases by Nef would be expected to up-regulate cyclin D 1 gene expression and promote the synthesis and stabilization of cyclin D 1 protein via Src-Ras-MAPK and Src-PI3K-mTOR signal transduction pathways, respectively [ 32 33 34 ] . Interestingly, our unpublished in vitro observations and published data showing marked expression of basic fibroblast growth factor in the interstitium of HIVAN kidneys [ 35 ] suggest that soluble mitogens may be important cofactors with HIV-1 expression to induce cyclin D 1 . Thus, interrupting HIV-1 gene expression should down-regulate cyclin D 1 and correct the phenotypic abnormalities in infected podocytes.

  • Aberrant promoter methylation changes that occur in cancer are associated with transcriptional repression and loss of function of the gene by interrupting the binding of proteins involved in transcription activator complex [ 12 ] . Our gene expression analysis by RT-PCR demonstrated that all tumors that showed methylation of MGMT and MLH1 also showed down-regulated expression, while RASSF1A and RARB genes showed down-regulation of mRNA levels in most of the methylated tumors.

  • Worse still, Y2K threatens to become the preferred Big Think Question for TV talk shows over the next 18 months, as modeled by Sam Donaldson ( This Week ). Interrupting IRS Commissioner Charles Rossotti's thoughtful discussion of IRS legislative reform, Donaldson bursts out with: "Are you ready for the year 2000?

  • The multiple ports allow changing of filters without interrupting the aerosol flow.


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