Words similar to integrins
Example sentences for: integrins
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The cell surface expressed integrins can control this process by physically interacting with the extracellular matrix proteins and other cell surface proteins on endothelial cells lining the blood vessel wall [ 1 ] . These integrins signal adhesion and migration by communicating with several tyrosine kinases inside the cell, including the Focal Adhesion Kinase (FAK) and Src family kinases [ 1 2 ] . Src kinases control the activation of FAK, as well as the tyrosine phosphorylation of critical substrates that regulate adhesion and migration [ 3 ] . Indeed, colon cancer cells with high metastatic potential have elevated levels of Src activity or activating mutations in the Src gene [ 4 5 ] . One Src substrate that is involved in regulating an important signaling node in this process is the adaptor protein p130 cas (Cas) [ 6 7 8 9 10 ] . Cas appears to play a central role in the transformation process by several oncogenes including ras, ornithine decarboxylase (ODC), v-Src, v-crk, and Bcr-Abl, as these tumors all have elevated levels of tyrosine phosphorylated Cas [ 6 11 12 13 ] . Cells from mice that lack Cas have much reduced migration and are resistant to transformation by v-Src, while expression of Cas anti-sense RNA in cells transformed with ras, v-Src or ODC result in reversion of the transformed phenotype [ 11 14 15 ] . Furthermore, increased expression of Cas can rescue cell migration and adhesion in cells expressing the tumor suppressor PTEN, and can enhance cell migration and adhesion in normal cells, with a major role being played by the substrate domain [ 16 17 ] .
Affinity chromatography with 125I surface labeled proteins resulted in the binding of proteins of the appropriate sizes of β1 integrins to both FN and III1-C columns.
CD81, a defining member of the tetraspanin superfamily, is widely expressed on human hematopoietic and other cells [ 2 ] . It associates on B cells with a signaling complex that includes CD19 and CD21 [ 3 ] , as well as associating with MHC class II molecules [ 4 ] and other tetraspanins [ 5 6 ] . On T cells, CD81 interacts with CD4, CD8, CD82, and selected integrins [ 7 8 9 10 ] .
These fractions typically contain caveolae and 'membrane rafts' thought to be enriched in active signaling complexes [ 34 35 43 ] . The fraction of the β1 integrins detected in the light membrane fractions represents no more than 5% of total β1 integrins (based on the densitometric analysis, not shown).
Taken together, these results indicate that the first type III repeat of fibronectin can serve as a cell binding domain and that both integrins and cell surface HSPGs function as receptors for this type III repeat.
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