Example sentences for: integrins

How can you use “integrins” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We utilized a monoclonal antibody screening method involving co-immunoprecipitation of integrins under non-stringent detergent conditions [ 30 31 ] . Using this approach, we have previously discovered specific associations between particular β1 integrins and other cell surface molecules including CD147/EMMPRIN [ 31 ] , and various tetraspanin (transmembrane-4 superfamily) proteins [ 30 32 33 ] . In this report we demonstrate for the first time that CD98 constitutively and specifically associates with intact β1 integrin heterodimers.

  • For example, statins have been proposed to cause co-localization of α-secretase and APP within lipid rafts [15,33]; statins might also induce modification of the structure and activity of a protein in the plasma membrane α-secretase complex, perhaps in an action similar to how statins bind and “lock” cell-surface integrins [34].

  • Only integrins that have bound their ligands are anchored to the cytoskeleton [ 64 65 ] . In our experiments, mature TGFβ 1 , α V β 6 integrin, and F-actin colocalize (Figure 1), suggesting association with and activation of this integrin.

  • About two decades ago, it became widely appreciated that many of the cell surface receptors that mediate cell–cell and cell–ECM interactions were structurally and functionally related, and the term “integrins” was coined to reflect the capacity of members of this family to integrate the extracellular and intracellular environment (Hynes 1987).

  • As described above, the syndecans may cooperate with β1 integrins and CD47 to activate the ERK signaling pathway in T cells [ 38 ] . A similar mechanism may apply to the adhesion of RASMCs to III1-C.

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