Example sentences for: integrin

How can you use “integrin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • A recent study demonstrated an interaction of latent TGFβ 1 with α V β 6 integrin, which led to an activation of latent TGFβ 1 [ 45 ] . Incubation of different tumor cells with mature TGFβ 1 resulted in a direct binding of TGFβ 1 to α V β 6 integrin.

  • Affinity-purified anti-α 2 β 1 integrin (MAB1988), anti-α v β 3 integrin (LM609), anti-MMP2 (MAB13405), and anti-VE-cadherin (MAB1989) monoclonal antibodies (mAbs) were purchased from Chemicon Intl; anti-Flt-1 (sc-316), anti-KDR (sc-6251), anti-Kinesin heavy chain (sc-13359), anti-Stanniocalcin (sc-14352), and anti-Grb2 were obtained from Santa Cruz Biotechnology Inc., and anti-β 1 integrin subunit mAbs (4B4), from Coulter Inc.

  • Thus for intact integrins in the context of mammalian cells, the integrin β chain apparently does contribute to the specificity of CD98 interaction.

  • The following antibodies were used in a dilution of 1:1,000: TGFβ 1 (Santa Cruz [sc], sc-146), p-Tyr (sc-7020), β 6 -integrin (sc-6632), α V -integrin (sc-6617), p125 FAK(sc-557), TGFβ 1 -RI (sc-402), TGFβ 1 -RII (sc-400-G), ERK1/2-P (sc-7383), SMAD2/3 (sc-6033), SOS1/2 (sc-259), p130 cas(UBI-06-500), PCNA (sc-56), p21 WAF1(sc-6246), p27 KIP(sc-1641), c-fos (sc-7202), c-jun (sc-44), raf1 (sc-133), p21 Ras(sc-35) and phospho-threonine antibody (New England Biolabs, # 9381).

  • For example, growth factor-induced localization of actin mRNA to the leading edge of fibroblasts is a dynamic, regulated process requiring actomyosin interactions and activation of the RhoGTPase pathway, as well as specific signal sequences in the 3' UTR of the message [ 9 10 11 12 ] . Moreover, disruption of the actin cytoskeleton using pharmacological agents also blocks the association of β-actin mRNA with microfilaments and prevents localization of the transcript to the cell periphery [ 7 13 ] . Mechanical forces exerted on cell surface integrin receptors, which anchor the actin cytoskeleton to the extracellular matrix, also produce changes in the localization of poly(A) mRNA and ribosomal proteins inside the cell [ 14 ] . Importantly, the localization of transcripts can serve as a key regulatory step in gene expression as inhibition of mRNA targeting can significantly impact cell function.


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