Words similar to integrin
Example sentences for: integrin
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[ 2 ] demonstrated the presence of α6β1 and αvβ3 integrins at the egg surface by indirect immunofluorescence and PCR, and showed involvement of the α6β1 integrin in sperm-egg fusion by peptide and antibody inhibition assays.
The expression of 5 known regulators of angiogenesis, KDR and α 2 integrin, VE-cadherin, MMP1, and MMP2, as well as 11 candidate genes (Figs.
The identification of VEGFR-1 and VEGFR-2 (KDR) was consistent with the observation that the stimulation of ECs with VEGF increases the expression of VEGFR-2, promoting myocardial revascularization [ 22 ] . We also detected the cell adhesion molecules VCAM-1, VE-Cadherin, and the α 2 integrin subunit, all known regulators of angiogenesis.
C3 exoenzyme was purified as previously described [ 25 ] . Anti-β1 integrin mAb 33B6 and anti α4β1 integrin mAb 19H8 were generated in this laboratory and have been previously described [ 27 28 ] . Rabbit polyclonal anti-Cdc42, -Rac1, -Rac2, -RhoA, and mouse monoclonal anti-Ras, were purchased from Santa Cruz Biotechnology (Santa Cruz, CA).
MAdCAM-1 is normally expressed in the gut, and its expression is dramatically amplified during inflammation [ 2 3 ] . The functional significance of increased appearance of MAdCAM-1 in IBD is supported by several reports which show that immunoneutralization of either MAdCAM-1 or its ligand, the α4β7 integrin, attenuate inflammation and mucosal damage in animal models of colitis [ 8 9 10 ] . However, since monoclonal antibodies directed against other ECAMs, particularly VCAM-1, can as well reduce disease activity in colitis models [ 11 12 13 14 ] , the literature suggests that MAdCAM-1 is probably necessary, but insufficient for the maximal penetrance of experimental and probably also clinical IBD.
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