Example sentences for: integrin

How can you use “integrin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We investigated the interaction of TGFβ 1 with the α V β 6 integrin and its influence on selected target genes known to be involved in cell cycle-regulated growth inhibition.

  • To test the latter hypothesis, we compared the total β1 integrin distribution with the distribution of the fraction of β1 integrins complexed with CD98 on HT 1080 cells (Fig.

  • Despite the molecular level of our understanding of integrin activation, a number of key questions remain unresolved.

  • Spectrin and protein 4.1 form a complex with actin filaments [ 17 26 ] that may be important in signaling in additional to forming a physical link between the cytoskeletal network and the cell membrane [ 27 ] . Furthermore, PI4K activity has been shown to associate with the actin cytoskeleton by biochemical detergent extraction [ 28 ] and is thought to specifically localize with α3β1 integrin [ 29 ] . PI4K catalyzes the production of phosphatidylinositol-4-phosphate, an intermediate in multiple phosphatidylinositol signaling pathways which itself can interact with actin binding proteins to regulate microfilament polymerization [ 30 ] . Our work now suggests that the mRNAs of these proteins are all positioned in close association with the actin cytoskeleton to permit efficient localization of their protein products.

  • The interaction of the α4β7 integrin on a subset of T cells, with its ligand, MAdCAM-1, on high venular and lymphoid endothelial cells has been shown to be support the entry of of these lymphocytes into the gut in IBD [ 8].


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