Example sentences for: integrin

How can you use “integrin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Thus, specificity for constitutive association with CD98 may reside in integrin α chain extracellular or transmembrane domains.

  • Our results clearly confirmed that GluR4 was present in the rat neonatal microglia used in our in vitro studies with domoic acid, demonstrating that the protocol used in our laboratory to isolate microglia did not appear to affect the presence of the AMPA glutamate receptor GluR4 subunits and their colocalization with the CD 11 b/c integrin.

  • The residues in the MIDAS motifs lie on three closely apposed loops located on the upper edge of the β-sheet, where they form the metal-binding site, with oxygen atoms in the aspartate, serine and threonine residues coordinating the metal ion [ 9 ] . In integrin α2β1, which is a collagen receptor, the metal-binding site also binds the collagen ligand through the conserved glutamate in a GFOGER motif (O = hydroxyproline) completing the coordination sphere of the metal [ 28 ] . In vivo, the binding of collagen at this site appears to be regulated through a conformational shift in which the loops forming the MIDAS site change from a closed to an open conformation [ 29 30 31 ] . Other proteins containing a domain with all three MIDAS motifs include the D-subunit of magnesium chelatase [ 32 ] , Ca-activated chloride-channel protein [ 33 34 ] , nitrate reductase (accession AAC79447), and the D subunit of nitric oxide reductase (accession AAC45374).

  • C3 exoenzyme was purified as previously described [ 25 ] . Anti-β1 integrin mAb 33B6 and anti α4β1 integrin mAb 19H8 were generated in this laboratory and have been previously described [ 27 28 ] . Rabbit polyclonal anti-Cdc42, -Rac1, -Rac2, -RhoA, and mouse monoclonal anti-Ras, were purchased from Santa Cruz Biotechnology (Santa Cruz, CA).

  • The α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) glutamate-4 receptor subunit (GluR4) and the integrin CD11b/c were visualized by indirect immunofluorescence using a dual labeling procedure.


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