Words similar to integrin

Example sentences for: integrin

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This notion is well supported by several reports that show that antibodies directed against either MAdCAM-1, or its lymphocyte ligand, the α4β7 integrin will significantly attenuate several indices of gut damage in experimental models of colitis [ 9 47 ] .
After binding to α V β 6 integrin, latent TGFβ 1 is activated by processing of latent TGFβ 1 by cleavage of the latency-associated Peptide (LAP) [ 45 46 47 48 49 50 51 52 53 54 55 56 57 ] . Recently, the interaction of latent TGFβ 1 with α V β 6 integrin has been shown [ 45 ] . After binding of latent TGFβ 1 to α V β 6 integrin, latent TGFβ 1 is activated by cleavage of the latency-associated peptide (LAP) [ 45 ] . This α V β 6 integrin is also expressed by pancreatic carcinoma cells [ 58 59 60 61 62 63 ] . We hypothesized that there is a SMAD-independent TGFβ 1 signaling pathway in TGFβ 1 -sensitive carcinoma cells.
Influence of TGFβ 1 on cell growth is well established, but the mechanisms are not fully understood [ 75 76 77 78 79 ] . Here, we assayed for the possible synergistic function of α V β 6 integrin on mature TGFβ 1 mediated growth inhibition in Panc-1 cells.
Such inside-out regulation of integrin affinity states is distinct from the outside-in signaling observed upon activation of most other transmembrane receptors (e.g.
In a reciprocal experiment, CD98 heavy chain was re-precipitated from an α3β1 integrin immunoprecipitate (Fig.