Example sentences for: integrin

How can you use “integrin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • 18 mice, contrary to what was observed previously [ 15 ] . The high-level expression of hCARΔcyt by double-negative (CD4 -CD8 -) thymocytes rendered this population readily transducible, suggesting that these early thymocytes express sufficient integrin co-receptors (e.g.

  • This phosphorylation is dependent on the integrity of the cytoskeleton, as disruption of actin filaments by cytochalasin D completely eliminated this effect, findings which have also been reported for several integrin signaling pathways [ 66 67 ] . Moreover, incubation of the TGFβ 1 sensitive carcinoma cells with TGFβ 1 caused immobilization of the docking protein p130 casand of the guanine nucleotide exchange factor SOS to the cytoskeleton.

  • Remarkably, preincubation with the MEK1 inhibitor PD98059 resulted in a reduced cytoskeletal immobilization and tyrosine phosphorylation of cellular proteins in response to stimulation with mature TGFβ 1 . This finding is in agreement with other observations that MEK1-mediated signal transduction is involved in cytoskeletal remodeling and integrin engagement [ 70 71 ] .

  • Haubner and colleagues, the authors of a paper in this month's PLoS Medicine , have previously developed a fluorine-labeled peptide, [ 18 F]Galacto-RGD, that has a high affinity for avß3 integrin.

  • Upon stimulation, a cellular signal induces a conformational change in the integrin cytoplasmic domain that propagates to the extracellular domain.


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