Words similar to integrin-mediated
Example sentences for: integrin-mediated
How can you use “integrin-mediated” in a sentence? Here are some example sentences to help you improve your vocabulary:
Activation of p125 FAK, a central step in integrin-associated signaling [ 72 73 ] , was determined to assess integrin-mediated signaling.
To determine whether binding of mature TGFβ 1 leads to integrin-mediated signaling, we looked at the status of integrin-cytoskeleton-associated proteins [ 66 67 ] after incubation with mature TGFβ 1 in selected carcinoma cell lines with different degrees of sensitivity to TGFβ 1 (Table 1).
The inside-out signaling protects the host from excessive integrin-mediated cell adhesion, which could, for example, lead to spontaneous aggregation of blood cells and have profound pathological consequences.
The involvement of Rho GTPases in regulating integrin dependent events such as leukocyte homotypic aggregation and in chemokine upregulation of integrin-mediated adhesion has recently been identified [ 18 19 ] . ADP-ribosylation of Rho in neutrophils by treatment with C3 not only inhibits cellular locomotion, but augments chemoattractant induced actin polymerization [ 20 21 ] . Moreover, inactivation of Rho in monocytic cells leads to accelerated formation of filopodia, and it has been proposed that Rho is a negative regulator of actin polymerization within this cell type [ 22 ] . Active Rho is also required for normal morphology, motility, and cytolytic activity of IL-2 activated NK cells [ 23 24 ] . We and others have demonstrated the importance of Rho in T lymphocyte activation [ 25 26 ] . Given the role played by Rho in the regulation of actin microfilaments in other cell types, and the indispensability of a functional actin cytoskeleton in lymphocyte motility and activation, it is of importance to study Rho's role in the regulation of T lymphocyte integrin function and maintenance of cytoskeletal organization.
In a variety of integrin-mediated signaling pathways, tyrosinephosphorylation of proteins immobilized to the cytoskeleton is enhanced [ 66 67 ] . The same was true in our experimental settings only for the TGFβ 1 -sensitive cells.
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