Words similar to integrin-mediated
Example sentences for: integrin-mediated
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To determine whether binding of mature TGFβ 1 leads to integrin-mediated signaling, we looked at the status of integrin-cytoskeleton-associated proteins [ 66 67 ] after incubation with mature TGFβ 1 in selected carcinoma cell lines with different degrees of sensitivity to TGFβ 1 (Table 1).
Thus, these proteins are good candidates to link the integrin-mediated TGFβ 1 signaling to the MAP kinase pathway, as was shown previously for signaling events induced by fluid stress or integrin mediated cell-adhesion in other cell types [ 71 84 85 86 87 88 89 90 91 ] .
In a variety of integrin-mediated signaling pathways, tyrosinephosphorylation of proteins immobilized to the cytoskeleton is enhanced [ 66 67 ] . The same was true in our experimental settings only for the TGFβ 1 -sensitive cells.
Activation of p125 FAK, a central step in integrin-associated signaling [ 72 73 ] , was determined to assess integrin-mediated signaling.
The involvement of Rho GTPases in regulating integrin dependent events such as leukocyte homotypic aggregation and in chemokine upregulation of integrin-mediated adhesion has recently been identified [ 18 19 ] . ADP-ribosylation of Rho in neutrophils by treatment with C3 not only inhibits cellular locomotion, but augments chemoattractant induced actin polymerization [ 20 21 ] . Moreover, inactivation of Rho in monocytic cells leads to accelerated formation of filopodia, and it has been proposed that Rho is a negative regulator of actin polymerization within this cell type [ 22 ] . Active Rho is also required for normal morphology, motility, and cytolytic activity of IL-2 activated NK cells [ 23 24 ] . We and others have demonstrated the importance of Rho in T lymphocyte activation [ 25 26 ] . Given the role played by Rho in the regulation of actin microfilaments in other cell types, and the indispensability of a functional actin cytoskeleton in lymphocyte motility and activation, it is of importance to study Rho's role in the regulation of T lymphocyte integrin function and maintenance of cytoskeletal organization.
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