Words similar to initiation
Example sentences for: initiation
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The uORFs are involved mechanistically in bringing about enhanced translation initiation under conditions that otherwise favor a general decrease in translation initiation [ 25 ] . Within the 5' UTR of countin mRNA, we find uORFs similar in number and in arrangement to those of GCN4 mRNA, the major mRNA regulated by yeast GCN2 [ 25 ] . Thus, we suggest that countin mRNA, and probably other as yet identified mRNAs, are translationally upregulated when IfkA phosphorylates eIF2α during the preaggregation period, or from 1 to 7 hours after the onset of development.
Although recent investigations have revealed several components involved in regulating the initiation of development [ 15 16 17 18 ] , little or no information exists on how the cells sense starvation and in particular amino acid deprivation.
This study was conducted among the participants of the Nurses' Health Study, a prospective cohort of 121,700 women who have completed biennial questionnaires on medical events and lifestyle factors since the initiation of the study in 1976, when the women were 30-55 years of age [ 11 ] . The study has been approved by the institutional review board at the Brigham and Women's Hospital, Boston.
Converging evidence from epidemiological and molecular studies suggests that infection of genital human papillomavirus (HPV) is causally linked to the development of CC [ 4 ] . Since only a small fraction of HPV-infected cervical intra-epithelial neoplastic (CIN) lesions progress to invasive cancer, these studies further suggest that in addition to HPV, other host genetic factors play a role in cervical carcinogenesis [ 5 ] . A number of molecular studies have identified genetic alterations in these two histologic types of CC and at various stages of precursor lesions [ 6 7 8 ] . Despite this molecular characterization, the genetic basis of CC initiation and progression is still very poorly understood.
Indeed, the analyses indicate that desferrioxamine not only increases the likelihood of lowering hepatic iron load, but also tends to induce larger reductions in hepatic iron among responders, even after controlling for the imbalance in HIC at study initiation.
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