Words similar to initiator
Example sentences for: initiator
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The Ymut2 site, which is the most important site for controlling basal expression, overlaps a potential initiator site fitting the consensus (5' CTT CCC TTT TCC 3') for the ribosomal protein Inr family with only one mismatched base [ 40].
The sequence of the ORF4L product (denoted PEVE Rep) is homologous to circoviral replication initiator (Rep) proteins (Figure 4).
While there is extensive crosstalk between the caspases, the two most common initiator pathways are the Fas/Fas ligand pathway, involving caspase 8 and caspase 10, and the mitochondrial pathway, triggering caspase 9 [ 24 25 ] . Caspase 3, a pivotal downstream protease, functions in virtually every caspase pathway and serves as an executioner in the cells by cleavage of downstream targets which lead to irreversible chromosomal degradation.
The essential step in plasma membrane destabilization and MP-release very likely is a caspase-dependent sphingomyelin hydrolysis, which leads to the production of ceramide [ 28 29 30 ] . It is possible, however, that sphingomyelin hydrolysis and MP-release may be a consequence of the action of initiator caspases or other ZVAD sensitive proteases rather than only executioner caspases [ 15 31 32 ] . Our study was performed in HUVEC culture, which may have particular properties in respect of MP release when compared with endothelial cells from other organs.
The McPromoter system consists of a generalized hidden Markov model of a promoter sequence, with six interpolated Markov chain submodels representing different segments of the promoter sequence from -250 to +50: upstream 1 and 2, TATA box, spacer, initiator and downstream.