Example sentences for: initiator

How can you use “initiator” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • 24 cells and primary mouse hepatocytes, through activation of the Fas receptor in a FasL-independent manner [ 19 25 ] . Moreover, GCDCA was demonstrated to activate both initiator and effector caspases, and that the apoptotic response can be blocked by Crm A, a caspase 8 inhibitor [ 25 ] . The mechanism by which bile acids stimulate the activation of Fas receptor remains unclear.

  • The initiator (Inr) element has been shown to be critical in positioning RNA polymerase II complex for transcription initiation in TATA-less promoters [ 39].

  • The sequence immediately flanking the dnaA gene is considered the origin of chromosomal replication, or oriC region [ 9 10 ] . This region contains several genes that encode proteins required for basic cellular functions, including the protein subunit of RNase P (RnpA), ribosomal protein L34 (RpmH), the replication initiator protein (DnaA), the beta subunit of DNA polymerase III (DnaN), the recombination repair protein RecF, and the DNA gyrase proteins GyrA and GyrB.

  • While there is extensive crosstalk between the caspases, the two most common initiator pathways are the Fas/Fas ligand pathway, involving caspase 8 and caspase 10, and the mitochondrial pathway, triggering caspase 9 [ 24 25 ] . Caspase 3, a pivotal downstream protease, functions in virtually every caspase pathway and serves as an executioner in the cells by cleavage of downstream targets which lead to irreversible chromosomal degradation.

  • Thus man "should be the initiator because of [his] stronger sex drive," while "the role of the woman is to respond."


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