Example sentences for: initiator

How can you use “initiator” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The Ymut2 site, which is the most important site for controlling basal expression, overlaps a potential initiator site fitting the consensus (5' CTT CCC TTT TCC 3') for the ribosomal protein Inr family with only one mismatched base [ 40].

  • The sequence of the ORF4L product (denoted PEVE Rep) is homologous to circoviral replication initiator (Rep) proteins (Figure 4).

  • While there is extensive crosstalk between the caspases, the two most common initiator pathways are the Fas/Fas ligand pathway, involving caspase 8 and caspase 10, and the mitochondrial pathway, triggering caspase 9 [ 24 25 ] . Caspase 3, a pivotal downstream protease, functions in virtually every caspase pathway and serves as an executioner in the cells by cleavage of downstream targets which lead to irreversible chromosomal degradation.

  • The essential step in plasma membrane destabilization and MP-release very likely is a caspase-dependent sphingomyelin hydrolysis, which leads to the production of ceramide [ 28 29 30 ] . It is possible, however, that sphingomyelin hydrolysis and MP-release may be a consequence of the action of initiator caspases or other ZVAD sensitive proteases rather than only executioner caspases [ 15 31 32 ] . Our study was performed in HUVEC culture, which may have particular properties in respect of MP release when compared with endothelial cells from other organs.

  • The McPromoter system consists of a generalized hidden Markov model of a promoter sequence, with six interpolated Markov chain submodels representing different segments of the promoter sequence from -250 to +50: upstream 1 and 2, TATA box, spacer, initiator and downstream.


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