Words similar to impaired
Example sentences for: impaired
How can you use “impaired” in a sentence? Here are some example sentences to help you improve your vocabulary:
Furthermore, we have found that combined mutation of Rlk and Itk leads to profound defects in TCR signaling associated with impaired activation of PLC-γ [ 20].
, to a membrane-localization tag) improve the function of mutant versions of Boi1-PH that are impaired in the ability to bind PIP 2 ? One possibility is that each of these mutant versions of Boi1 retains at least a slight affinity for PIP 2 and that the myristoyl group causes these mutant PH domains to be apposed close enough to the lipid bilayer to enable the residual PIP 2 -binding activity to now be sufficient for binding to PIP 2 . We speculate that, just as binding to PS may serve to position the PH domain of wild-type Boi1 near the plasma membrane in a manner that facilitates binding to PIP 2 , the myristoyl group may help to situate the PH domain of the mutant versions of Boi1-PH at the plasma membrane in a manner that facilitates binding to PIP 2 .
In contrast, the KK mutant appears to be impaired more in the ability to recognize specifically PIP 2 than in the ability to bind non-specifically to acidic phospholipids.
Genes identified using enrichment or screening protocols include Rv2962c and Rv2958c (probable glucuronsyl transferases), Rv2220 (glutamine synthetase A1), Rv3913-Rv3914 (thioredoxin, thioredoxin reductase) and Rv2416c ( eis, unknown function) [ 14 15 22 29 ] . By screening insertional mutants of M. smegmatis, Lagier et al [ 30 ] isolated 8 mutants with impaired ability to survive in human peripheral blood monocyte-derived macrophages and identified the M. tuberculosis gene corresponding the mutated M. smegmatis gene for five of them.
4. Research is needed on referral strategies for more severely impaired, non-responsive patients, to assist them in gaining access to resources already available in their communities.
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