Example sentences for: impair

How can you use “impair” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • An accumulation of 4-HNE-conjugated protein has been detected in lesions of aging-related diseases, including Parkinson's disease [ 53 ] and Alzheimer's disease [ 54 ] . It also accumulates in the affected neuronal tissues of experimental animals experiencing brain ischemia [ 55 56 ] and traumatic spinal cord injury [ 57 ] . 4-HNE can impair synaptosomal membrane proteins, glutamate transport and importantly, mitochondrial functions [ 58 59 ] . Evidence indicates that 4-HNE increases neuronal susceptibility to oxidative stress [ 60 ] and serves as a mediator of oxidative stress that leads to neuronal apoptosis [ 61 ] . As indicated in the Introduction, 4-HNE has been implicated in some ocular pathological conditions [ 19 20 ] .

  • In addition, and somewhat ironically, the most commonly used agents (like steroids, calcineurin inhibitors, and rapamycin) are also known to impair normal islet function and/or insulin action.

  • A behavior of Boi1 that is affected by mutations that impair binding to phospholipids is the localization of Boi1 to buds.

  • Although prior press reports have wondered if the 76-year-old Suharto's failing health would impair his ability to lead his country out of the current crisis, neither of today's Times stories emphasize this.

  • Lethal dose radiation followed by bone marrow transplant can significantly impair the responsiveness of anti-tumor CD8 +T cells, dendritic cells, eosinophiles and macrophages [ 8 ] , and is a clinically undesirable therapeutic modality.


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