Words similar to impair
Example sentences for: impair
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An accumulation of 4-HNE-conjugated protein has been detected in lesions of aging-related diseases, including Parkinson's disease [ 53 ] and Alzheimer's disease [ 54 ] . It also accumulates in the affected neuronal tissues of experimental animals experiencing brain ischemia [ 55 56 ] and traumatic spinal cord injury [ 57 ] . 4-HNE can impair synaptosomal membrane proteins, glutamate transport and importantly, mitochondrial functions [ 58 59 ] . Evidence indicates that 4-HNE increases neuronal susceptibility to oxidative stress [ 60 ] and serves as a mediator of oxidative stress that leads to neuronal apoptosis [ 61 ] . As indicated in the Introduction, 4-HNE has been implicated in some ocular pathological conditions [ 19 20 ] .
In addition, and somewhat ironically, the most commonly used agents (like steroids, calcineurin inhibitors, and rapamycin) are also known to impair normal islet function and/or insulin action.
A behavior of Boi1 that is affected by mutations that impair binding to phospholipids is the localization of Boi1 to buds.
Although prior press reports have wondered if the 76-year-old Suharto's failing health would impair his ability to lead his country out of the current crisis, neither of today's Times stories emphasize this.
Lethal dose radiation followed by bone marrow transplant can significantly impair the responsiveness of anti-tumor CD8 +T cells, dendritic cells, eosinophiles and macrophages [ 8 ] , and is a clinically undesirable therapeutic modality.