Words similar to impairs
Example sentences for: impairs
How can you use “impairs” in a sentence? Here are some example sentences to help you improve your vocabulary:
To test the possibility that protein aggregates might be formed when any Rab GTPase is overexpressed with a mutation that impairs nucleotide binding, we examined the localization of four additional members of the Rab family containing amino acid substitutions in the N(T)KxD motif.
As mentioned earlier, the lack of formal life cycle calculations impairs drawing conclusions about the net public health benefits of increased residential insulation.
Previous studies by others had shown that the ectopic expression of PTEN in anchorage-independent tumor cells greatly reduced their ability to grow in soft agar [ 4 5 6 ] . In this latter situation, however, the forced expression of ectopic PTEN effectively impairs cellular proliferation in general, even under two-dimensional culture conditions where the cells are attached to substratum [ 4 6 7 8 9 10 18 33 44 ] . It was therefore difficult to discern from these experiments how effectively and selectively PTEN participates in anchorage-dependent growth control.
In an earlier investigation on the role of the p51 subunit of HIV-1 RT, we demonstrated that decrease in size of its β7-β8 loop impairs the catalytic function of the heterodimer [ 15 ] . In the present studies, we demonstrate that maintaining the wild type size of this loop in the p51 subunit is critical for dimerization of the enzyme and its catalytic activity.
T790M in the context of either transiently expressed wild-type EGFR or the mutant alleles del L474–E749;A750P or L858R impairs inhibition by gefitinib or erlotinib as assessed by autophosphorylation.
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