Words similar to immunocompromised
Example sentences for: immunocompromised
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To examine whether IPCs are similarly responsive to glucose stimulation in vivo, we performed a series of IPC grafting experiments in immunocompromised recipient mice.
A CMV infection, in vivo , can contribute to the net immunosuppressive status of the immunocompromised patient [ 11 ] . A CMV infection can result in the production of certain immune effector proteins (cytokines and chemokines) that may affect latency in the EBV infected B-cells [ 77 ] . The production of these cytokines and chemokines from a CMV superinfected BJAB-B1 or P3HR-1 cell may affect neighboring cells and therefore cause EBV reactivation, implying that CMV could be having an indirect effect on EBV latency.
This mutation has also been detected in clinical isolates from patients immunocompromised [ 12 ] or with AIDS [ 19 ] as well as resistant HSV selected in tissue culture [ 15 18 ] . Interestingly, this mutation was present in ACV rclinical isolates obtained during reactivation in the absence of drug pressure, as well as in ACV rstrains which evolved during ACV therapy and were followed by ACV-susceptible isolates at the next reactivation [ 19 ] .
It would be of interest to apply the PEA to an extensive series of clinical isolates, particularly isolates obtained from severely immunocompromised patients, in order to evaluate the proportions of resistant virus that occur within different clinical isolates.
S. maltophilia is an important pathogen in nosocomial infections of immunocompromised patients suffering from cancer, cystic fibrosis, drug addition, AIDS and in patients with organ transplants and on dialysis [ 30 31 32 ] . This organism is inherently resistant to most antibiotics due to its low outer membrane permeability [ 33 ] and to β-lactam containing antibiotics due to the production of a chromosomally expressed group 2e β-lactamase (L2) and a group 3c β-lactamase (L1) [ 34 35 ] . L1 has been cloned, over-expressed, and partially characterized by kinetic and crystallographic studies [ 36 37 ] . The enzyme exists as a homotetramer of ca. 118 kDa in solution and in the crystalline state.
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