Words similar to immunocompromised
Example sentences for: immunocompromised
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Cryptosporidiosis is caused by a coccidian parasite, Cryptosporidium , which is transmitted in its infective form, the oocyst, by the fecal-oral route [ 1 ] . It causes self-limited, watery diarrhea in immunocompetent individuals but can be severe and life threatening in people with immunosuppressive conditions [ 2 ] . Because of the severe nature of the disease in the immunocompromised, most epidemiologic studies have focussed on people with HIV/AIDS and other immunosuppressed states [ 3 4 5 6 7 8 9 ] . What is known about transmission patterns in the general US population is based on studies undertaken during outbreaks of the disease, usually waterborne [ 10 11 12 13 14 15 16 ] . Even though cryptosporidiosis is a reportable disease, limited data are available on the routes of endemic transmission and on accurate incidence rates of cryptosporidiosis, especially in the immunocompetent population.
To both accelerate the development of vascular pathology and to deepen the immunocompromised state, these mice were irradiated with a sublethal dose of gamma radiation (300 Rads) at 4 months of age.
A CMV infection, in vivo , can contribute to the net immunosuppressive status of the immunocompromised patient [ 11 ] . A CMV infection can result in the production of certain immune effector proteins (cytokines and chemokines) that may affect latency in the EBV infected B-cells [ 77 ] . The production of these cytokines and chemokines from a CMV superinfected BJAB-B1 or P3HR-1 cell may affect neighboring cells and therefore cause EBV reactivation, implying that CMV could be having an indirect effect on EBV latency.
S. maltophilia is an important pathogen in nosocomial infections of immunocompromised patients suffering from cancer, cystic fibrosis, drug addition, AIDS and in patients with organ transplants and on dialysis [ 30 31 32 ] . This organism is inherently resistant to most antibiotics due to its low outer membrane permeability [ 33 ] and to β-lactam containing antibiotics due to the production of a chromosomally expressed group 2e β-lactamase (L2) and a group 3c β-lactamase (L1) [ 34 35 ] . L1 has been cloned, over-expressed, and partially characterized by kinetic and crystallographic studies [ 36 37 ] . The enzyme exists as a homotetramer of ca. 118 kDa in solution and in the crystalline state.
Activated STAT5 proteins are detected in reduced levels in lymphocytes recovered from HIV-infected patients and immunocompromised mice.
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