Example sentences for: immunocompetent

How can you use “immunocompetent” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • After four serial passages in the immunocompetent mice, the infection became completely refractory to ACV treatment.

  • Sub-optimal therapy of immunocompetent mice with either VCV or FCV did not readily select for HSV-mutants resistant to either ACV or PCV, suggesting that selection of resistance with either prodrug remains difficult using this system.

  • Cryptosporidiosis is caused by a coccidian parasite, Cryptosporidium , which is transmitted in its infective form, the oocyst, by the fecal-oral route [ 1 ] . It causes self-limited, watery diarrhea in immunocompetent individuals but can be severe and life threatening in people with immunosuppressive conditions [ 2 ] . Because of the severe nature of the disease in the immunocompromised, most epidemiologic studies have focussed on people with HIV/AIDS and other immunosuppressed states [ 3 4 5 6 7 8 9 ] . What is known about transmission patterns in the general US population is based on studies undertaken during outbreaks of the disease, usually waterborne [ 10 11 12 13 14 15 16 ] . Even though cryptosporidiosis is a reportable disease, limited data are available on the routes of endemic transmission and on accurate incidence rates of cryptosporidiosis, especially in the immunocompetent population.

  • Foodborne outbreaks of cryptosporidiosis in which the vehicle of transmission was identified are few and only one outbreak in Maine was definitively associated with contaminated fresh-pressed apple cider [ 28 ] . Other foodborne outbreaks due to cryptosporidiosis have implicated food handlers [ 29 ] and social events [ 30 31 ] . Person-to-person outbreaks have been better documented, such as those in hospitals [ 32 33 34 35 36 37 ] and day care centers [ 38 39 ] . It is becoming increasingly evident that cryptosporidiosis is one of the multitude of enteric pathogens that is endemic in hospital and day care settings [ 40 41 42 43 ] . Other routes of exposure to Cryptosporidium may be responsible for sporadic disease in the general population such as specific sexual contact with an infected individual [ 44 45 46 ] , travel to endemic countries [ 47 48 49 50 ] , and contact with animals, both domestic and livestock [ 1 2 51 52 ] . Recent studies in Australia have demonstrated that exposure to persons with diarrhea and swimming in public pools rather than consumption of untreated tap water are the sources of community-acquired cryptosporidiosis in that country [ 53 ] . The relative contribution for each of these modes of transmission to the total burden of sporadic cryptosporidiosis among immunocompetent persons continues to be unknown in the U.S.

  • injection of suckling mice induces vascular lesions in the aorta and pulmonary artery, which are characterized by cellular infiltrates containing T-lymphocytes [ 36 ] . A more recent study describes the development of MCMV induced vascular lesions in the aorta of both immunocompetent mice and those lacking IFN-γ responsiveness where IFN-γ is determined to be a major antiviral factor preventing the long term persistence of aortic vascular lesions [ 18 ] . The present study focused on neointima formation, which was seen only in immunocompromised mice.


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