Words similar to hypervariable
Example sentences for: hypervariable
How can you use “hypervariable” in a sentence? Here are some example sentences to help you improve your vocabulary:
This region, commonly referred to as the hypervariable domain, plays a major role in the subcellular targeting and functional specificity of each Rab protein [ 49 ] . In accord with this view, replacement of the hypervariable domain of Rab24(wt) with the corresponding domain from Rab1B, caused the resulting chimera to exhibit a discrete juxtanuclear Golgi-like fluorescence pattern typical of Rab1B in 293 cells [ 50 51 ] . (Fig.
Minisatellites of the hypervariable family (20-50 bp repeat size) are dispersed throughout the genome but, as expected [ 51], show sharp spikes in subtelomeric regions of most chromosomes.
Identical structures were seen when immunofluorescence microscopy was performed with antibodies against the N-terminal myc epitope or the C-terminal hypervariable domain of Rab24, indicating that the immunofluorescence pattern reflected the localization of full-length mycRab24(D123I).
To confirm the importance of the Rab24 hypervariable domain for targeting to inclusion bodies, we performed the reciprocal experiment, replacing the C-terminal domain of Rab1B(wt) or Rab1B(N121I) with the hypervariable domain from Rab24.
To determine whether the hypervariable domain of Rab24 was sufficient to promote the formation of inclusion bodies when fused to a heterologous protein, we prepared fusion constructs with enhanced green fluorescent protein (EGFP) containing either full-length Rab24(D123I) or just the Rab24 C-terminal domain.