Words similar to hypervariable

Example sentences for: hypervariable

How can you use “hypervariable” in a sentence? Here are some example sentences to help you improve your vocabulary:

The C-terminal hypervariable domain of Rab24 is required for the formation of inclusions
At the present time, the T3197C nucleotide substitution is considered a polymorphism and it is not thought to have pathogenic significance by itself [ 31 ] . Although most pathogenic mutations are heteroplasmic, many homoplasmic mutations have been reported to have synergistic effects in the presence of other primary mutations [ 32 33 ] . The only difference in mtDNA between the affected child and the asymptomatic mother is the A189G mutation in the hypervariable D-loop region.
To confirm the importance of the Rab24 hypervariable domain for targeting to inclusion bodies, we performed the reciprocal experiment, replacing the C-terminal domain of Rab1B(wt) or Rab1B(N121I) with the hypervariable domain from Rab24.
Most notably, replacement of hypervariable domain of Rab1B(N121I) with the corresponding C-terminal region from Rab24 caused a major change in the localization of the chimera from a predominant cytoplasmic distribution typical of Rab1B(N121I) (Fig.
To generate Rab24 fusions with Enhanced Green Fluorescent Protein (EGFP), cDNAs encoding full-length Rab24(wt) or Rab24(D123I), or the Rab24 C-terminal hypervariable domain (residues 166-203) were generated with flanking KpnI and BamHI sites and subcloned into pEGFP-C1 (Clontech Inc., Palo Alto, CA) so that the Rab inserts were in-frame with a 5' EGFP coding sequence.