Words similar to hypertensive
Example sentences for: hypertensive
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These data, along with the previous studies that confirmed morphological evidence of apoptosis and biochemical evidence of caspase-3 activation in these kidneys [ 7 ] , showed a role for the Fas/FasL pathway in promoting the loss of kidney function that develops in the setting of hypertensive nephrosclerosis in this model.
The role of the Fas/FasL pathway in human hypertensive nephrosclerosis remains to be determined.
Hypertension is a common medical problem in the United States, occurring in as many as 43 million individuals [ 1 ] . While end-stage renal failure represents the second most common cause of end-stage renal disease [ 2 ] , perhaps only 1 in 2,500 hypertensive patients develops clinically important hypertensive nephrosclerosis.
Interestingly, a similar whole-body accumulation of plant sterols, less severe than in human sitosterolemia, has been reported recently in SHR, SHRSP and WKY rats, but not in the other genetically related rat strains, such as SD, Wistar and WKA rats [ 16 ] . These rats exhibit defects at two levels: increased absorption of sterols (plant and animal) at the intestinal level and decreased excretion of sterols into bile [ 16 ] . The higher sterol absorption in the intestine and the lower biliary excretion of plant sterols in these rat strains led us to hypothesise that Abcg5 or Abcg8 gene mutations may be responsible for the sitosterolemia observed in these hypertensive rats.
We did not observe any differences between the staining patterns observed for the control rat strains (Wistar or SD) and the mutant hypertensive strains (SHR, SHRSP).
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