Words similar to hoxc-

Example sentences for: hoxc-

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Our studies of chondrocytes from Hoxc-8 transgenic mice reveal several interesting results: in vivo , chondrocytes remain relatively immature, with few progressing to hypertrophy in Hoxc-8 transgenic mice.
Such an effect would be consistent with the accumulation of immature, proliferating chondrocytes in Hoxc-8 transgenetic mice [ 1 ] . We therefore characterized cell proliferation in Hoxc-8 transgenic chondrocytes.
Figure 3shows that Hoxc-8 transgenic chondrocytes morphologically appeared normal and were able to produce Collagens II and X, and sulfated proteoglycans (Panels C, G, I, D, H, J and B, F respectively).
To distinguish these latter two possibilities, we analyzed BrdU incorporation into chondrocytes in Hoxc-8 transgenic mice in vivo . Multiple sections were examined from each embryo and showed incorporation of BrdU four hours after labeling.
The same caveat applies to elevated expression in Hoxc-8 transgenic cells of p130, which is also known to be linked to cell cycle exit and FGF response [ 39 ] . While the profile of gene expression changes in Hoxc-8 transgenic mice is suggestive of interactions between the various gene products, further studies will be required to mechanistically link the gene expression differences to the maturational delay in the Hoxc-8 transgenic cartilage.