Words similar to hoxc-
Example sentences for: hoxc-
How can you use “hoxc-” in a sentence? Here are some example sentences to help you improve your vocabulary:
Previously, we [ 1 ] found that upon overexpression of Hoxc-8, the vertebral cartilages accumulate immature chondrocytes, and we showed that these cells are proliferating cells by virtue of staining for Proliferating Cell Nuclear Antigen (PCNA).
To examine this function in more detail, we employed a culture system that facilitates chondrocyte maturation and cartilage formation, and closely recapitulates the in vivo situation [ 11 ] . The micromass system has been used extensively for studies of cartilage formation from limb mesenchyme [ 10 11 12 13 ] and also for culture of chondrocytes in high density [ 14 ] . Here, we have adapted the system to neonatal mouse rib chondrocytes, to study the role of Hoxc-8 in chondrocyte maturation.
As shown in Figure 8, Hoxc-8 expression is elevated in Hoxc-8 transgenic mice, as expected [ 23 ] . Differences also exist between controls and transgenics in expression levels for several genes involved in cartilage development.
While additional measurements at later stages of development would be needed to confirm whether this is a continuous trend for cartilage development in late pregnancy in Hoxc-8 overexpressing animals, these results were initially unexpected: The phenotype of Hoxc-8 transgenic animals at 17.
To distinguish these latter two possibilities, we analyzed BrdU incorporation into chondrocytes in Hoxc-8 transgenic mice in vivo . Multiple sections were examined from each embryo and showed incorporation of BrdU four hours after labeling.
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