Words similar to hoxc-
Example sentences for: hoxc-
How can you use “hoxc-” in a sentence? Here are some example sentences to help you improve your vocabulary:
To distinguish these latter two possibilities, we analyzed BrdU incorporation into chondrocytes in Hoxc-8 transgenic mice in vivo . Multiple sections were examined from each embryo and showed incorporation of BrdU four hours after labeling.
The same caveat applies to elevated expression in Hoxc-8 transgenic cells of p130, which is also known to be linked to cell cycle exit and FGF response [ 39 ] . While the profile of gene expression changes in Hoxc-8 transgenic mice is suggestive of interactions between the various gene products, further studies will be required to mechanistically link the gene expression differences to the maturational delay in the Hoxc-8 transgenic cartilage.
We previously reported [ 1 ] that Hoxc-8 transgenic mice exhibit profound defects in cartilage, particularly in the rib cage and vertebral column.
Our studies of chondrocytes from Hoxc-8 transgenic mice reveal several interesting results: in vivo , chondrocytes remain relatively immature, with few progressing to hypertrophy in Hoxc-8 transgenic mice.
The transcriptional regulatory activities of Smad1 in the nucleus are associated with its ability to directly bind to DNA [ 12 ] , its interaction with other DNA-binding transcription factors, such as OAZ, SIP1 and Hoxc-8 [ 13 14 15 ] , and also its interaction with the master transcriptional co-activator CBP/p300 [ 16 ] . Smad4 is an essential functional partner in Smad-regulated transcription and also interacts with CBP/p300 via a domain within the central linker region named as SAD (Smad Activation Domain) [ 13 ] . Since CBP/p300 has intrinsic histone acetyltransferase (HAT) activity and participates in chromatin remodeling, the recruitment of CBP/p300 into the DNA-binding complexes of Smad1 and Smad4 is likely a critical step in Smad-regulated gene activation.
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