Words similar to hoxc-
Example sentences for: hoxc-
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This finding was unexpected in light of the severe cartilage defects in Hoxc-8 transgenic mice [ 1 ] . However, the possibility remained that, despite apparently normal maturation, proliferation of chondrocytes could be affected by the Hoxc-8 overexpression.
4%, with a trend towards lower rates of incorporation in developmentally older embryos with higher Hoxc-8 transgene expression levels (TA/TA TR/+; Figure 4, Panel F).
The transcriptional regulatory activities of Smad1 in the nucleus are associated with its ability to directly bind to DNA [ 12 ] , its interaction with other DNA-binding transcription factors, such as OAZ, SIP1 and Hoxc-8 [ 13 14 15 ] , and also its interaction with the master transcriptional co-activator CBP/p300 [ 16 ] . Smad4 is an essential functional partner in Smad-regulated transcription and also interacts with CBP/p300 via a domain within the central linker region named as SAD (Smad Activation Domain) [ 13 ] . Since CBP/p300 has intrinsic histone acetyltransferase (HAT) activity and participates in chromatin remodeling, the recruitment of CBP/p300 into the DNA-binding complexes of Smad1 and Smad4 is likely a critical step in Smad-regulated gene activation.
Combined with the fact that some, albeit fewer, hypertrophic cells are present, the accumulation of proliferating chondrocytes suggests that Hoxc-8 regulates the rate of progression of chondrocytes to maturity [ 1 ] . In line with this interpretation, the in vivo BrdU incorporation assays suggested that cell cycle progression of chondrocytes may be decreased in transgenic animals with higher Hoxc-8 transgene expression levels.
If fewer immature cells enter the cell cycle in a given time interval, this is consistent with, and would explain the increased steady-state numbers of chondrocytes upon Hoxc-8 overexpression.
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