Words similar to hoxc-

Example sentences for: hoxc-

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Our studies of chondrocytes from Hoxc-8 transgenic mice reveal several interesting results: in vivo , chondrocytes remain relatively immature, with few progressing to hypertrophy in Hoxc-8 transgenic mice.
The same caveat applies to elevated expression in Hoxc-8 transgenic cells of p130, which is also known to be linked to cell cycle exit and FGF response [ 39 ] . While the profile of gene expression changes in Hoxc-8 transgenic mice is suggestive of interactions between the various gene products, further studies will be required to mechanistically link the gene expression differences to the maturational delay in the Hoxc-8 transgenic cartilage.
Yet, even if transgene expression was reduced in culture, the important implication of our results is that the downstream biological effects of at least 6 days of Hoxc-8 overexpression in vivo are reversible.
As fewer hypertrophic cells are present in Hoxc-8 transgenics, and cartilage maturation is delayed in Hoxc-8transgenic animals [ 1 ] , one would expect to see decreased Collagen X mRNA levels [ 27 ] . Yet, the data clearly indicate that mRNA expression is elevated in transgenic rib chondrocytes.
Alternatively, it is conceivable that the Hoxc-8 transgene could be silenced as cells are isolated from the animal, returning cells to their normal phenotype.