Words similar to hoxc-

Example sentences for: hoxc-

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As fewer hypertrophic cells are present in Hoxc-8 transgenics, and cartilage maturation is delayed in Hoxc-8transgenic animals [ 1 ] , one would expect to see decreased Collagen X mRNA levels [ 27 ] . Yet, the data clearly indicate that mRNA expression is elevated in transgenic rib chondrocytes.
Given our inability to distinguish Hoxc-8 transgenic cells from controls by parameters for either cell differentiation or proliferation, we sought to determine which molecular differences exist in our transgenic mice associated with the documented deficiencies in cartilage maturation [ 1 ] . To this end, we analyzed gene expression in freshly isolated primary rib chondrocytes from Hoxc-8 transgenic animals [ 1 ] . Real-time quantitative PCR was performed.
This finding was unexpected in light of the severe cartilage defects in Hoxc-8 transgenic mice [ 1 ] . However, the possibility remained that, despite apparently normal maturation, proliferation of chondrocytes could be affected by the Hoxc-8 overexpression.
This could occur through two different mechanisms: ( i ) Hoxc-8 actively recruits cells into the chondrocyte lineage and maintains them in the proliferating state; or ( ii ) Hoxc-8 inhibits a specific step in chondrocyte maturation.
To assess chondrocyte proliferation in Hoxc-8 transgenic mice, we performed in vivo BrdU labeling experiments.