Words similar to hoxc-

Example sentences for: hoxc-

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This could occur through two different mechanisms: ( i ) Hoxc-8 actively recruits cells into the chondrocyte lineage and maintains them in the proliferating state; or ( ii ) Hoxc-8 inhibits a specific step in chondrocyte maturation.
We found a similar phenotype upon overexpression of Hoxd-4 in our transgenic system (Kappen, manuscript in preparation), whereas overexpression of the LIM-homeodomain transcription factor Isl-1 did not cause abnormalities in cartilage but other developmental defects [ 1 9 ] . The observation that cartilage is affected by misregulation of Hoxc-8 and Hoxd-4, but not by a divergent homeobox gene, indicates that the capacity to regulate cartilage differentiation is specific to homeobox genes of the Hox subclass.
Interestingly, when primary chondrocytes from Hoxc-8 transgenic mice were assayed, they showed the same cell cycle kinetics as chondrocytes from control animals.
Taken together, these results establish alterations in gene expression upon overexpression of the Hoxc-8 transgene in the developing skeleton.
Our studies of chondrocytes from Hoxc-8 transgenic mice reveal several interesting results: in vivo , chondrocytes remain relatively immature, with few progressing to hypertrophy in Hoxc-8 transgenic mice.