Words similar to hoxa
Example sentences for: hoxa
How can you use “hoxa” in a sentence? Here are some example sentences to help you improve your vocabulary:
However, Hoxa3 +/- Pax1 -/-compound mutants were not completely missing either cytokine analyzed, and the magnitude of the decrease was variable between pools.
Combined with our previous data, this result suggests that the decrease in DP cell numbers seen in the Hoxa3-Pax1 compound mutants is both due to an increase in the number of pre-DP and DP cells undergoing apoptosis as well as a decrease in the number of proliferating DP.
Our previous analysis of the Hoxa3 +/- Pax1 -/-compound mutant thymocyte phenotype showed a specific partial block at the TN to DP transition, associated with increased apoptosis at both the TN4/pre-DP and DP subsets, and a 10-fold decrease in DP cell numbers [ 29 ] . Using BrdU analysis, we compared the proliferation of Hoxa3 +/- Pax1 -/-fetal thymocytes during the TN to DP transition compared to littermate controls.
In the Hoxa3,Pax1 compound mutants, cell-autonomous TEC defects cause a partial block at the DN-DP transition, so thymocytes do progress to DP and SP stages, albeit at reduced frequencies [ 29 ] . TEC defects are seen as early as E12.
Hoxa3 +/- Pax1 -/-compound mutants had decreased transcription of both cytokines relative to all other genotypes, including Pax1 -/-single mutants.
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