Example sentences for: hoxa

How can you use “hoxa” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • However, Hoxa3 +/- Pax1 -/-compound mutants were not completely missing either cytokine analyzed, and the magnitude of the decrease was variable between pools.

  • Combined with our previous data, this result suggests that the decrease in DP cell numbers seen in the Hoxa3-Pax1 compound mutants is both due to an increase in the number of pre-DP and DP cells undergoing apoptosis as well as a decrease in the number of proliferating DP.

  • Our previous analysis of the Hoxa3 +/- Pax1 -/-compound mutant thymocyte phenotype showed a specific partial block at the TN to DP transition, associated with increased apoptosis at both the TN4/pre-DP and DP subsets, and a 10-fold decrease in DP cell numbers [ 29 ] . Using BrdU analysis, we compared the proliferation of Hoxa3 +/- Pax1 -/-fetal thymocytes during the TN to DP transition compared to littermate controls.

  • In the Hoxa3,Pax1 compound mutants, cell-autonomous TEC defects cause a partial block at the DN-DP transition, so thymocytes do progress to DP and SP stages, albeit at reduced frequencies [ 29 ] . TEC defects are seen as early as E12.

  • Hoxa3 +/- Pax1 -/-compound mutants had decreased transcription of both cytokines relative to all other genotypes, including Pax1 -/-single mutants.


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