Words similar to hoxa
Example sentences for: hoxa
How can you use “hoxa” in a sentence? Here are some example sentences to help you improve your vocabulary:
Our previous analysis of the Hoxa3 +/- Pax1 -/-compound mutant thymocyte phenotype showed a specific partial block at the TN to DP transition, associated with increased apoptosis at both the TN4/pre-DP and DP subsets, and a 10-fold decrease in DP cell numbers [ 29 ] . Using BrdU analysis, we compared the proliferation of Hoxa3 +/- Pax1 -/-fetal thymocytes during the TN to DP transition compared to littermate controls.
It is also possible that some of the differences seen between Hoxa3 +/- Pax1 -/-and cytokine mutant phenotypes reflect different effects of cytokines at fetal and adult stages.
Our results support a critical role for microenvironment created by TECs in regulating thymocyte proliferation during the TN to DP transition, and show that this function is disrupted in Hoxa3,Pax1 compound mutants.
Hoxa3 and Pax1 by PCR as described previously [ 29 ] . Comparisons were made between littermates from the same colony.
Our previous analysis reported decreased DP cell number and increased apoptosis in both the pre-DP and DP stages in these mutants [ 29 ] . DP cell numbers in both this and our previous study were decreased 10-fold in the Hoxa3 +/- Pax1 -/-compound mutants.