Words similar to hoxa

Example sentences for: hoxa

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Cytokine production is decreased in the Hoxa3 +/- Pax1 -/-fetal thymus
Insufficiencies of multiple cytokines might be involved in the changes in proliferation and cell death at the CD44 -25 -and DP stages in Hoxa3-Pax1 compound mutants.
For example, SCF and IL-7 have been shown to have synergistic functions [ 62 63 ] . Therefore, changes in multiple cytokines in Hoxa3 +/- Pax1 -/-mutants would be expected to have complex effects on thymocyte development that could be difficult to predict.
Several genes expressed specifically in the normal male foreskin fibroblasts have been previously implicated in male genital development, including HOXA13 , the T-box genes, BMP4 and DWnt2 . Mutations in HOXA13 can cause distal limb and urogenital-tract malformations such as male hypospadias in hand-foot-genital syndrome [ 21 ] . T-box genes ( TBX ) are essential early regulators of limb development and also appear to be involved in male genital development [ 22 23 ] . Mutations in TBX3 cause the ulnar-mammary syndrome characterized by limb, apocrine, and genital developmental abnormalities [ 23 ] . Expression of T-box genes 2, 3, and 5 was significantly higher in normal male foreskin fibroblasts than in AIS genital fibroblasts.
Our results provide direct genetic evidence for these functions of TECs, by showing that these processes are defective in mutants with a primary TEC differentiation defect (the Hoxa3,Pax1 compound mutants).