Words similar to hoxd-

Example sentences for: hoxd-

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Hoxd-4 transgenic mice were generated using the same transactivator strain crossed to the IE-d4-70 transresponder strain [ 1 ] . Maintenance and genotyping of transgenic mice was done as described before [ 1 23 ] . Unless otherwise noted, cells and samples were obtained from animals hemizygous for both transgenes.
We found a similar phenotype upon overexpression of Hoxd-4 in our transgenic system (Kappen, manuscript in preparation), whereas overexpression of the LIM-homeodomain transcription factor Isl-1 did not cause abnormalities in cartilage but other developmental defects [ 1 9 ] . The observation that cartilage is affected by misregulation of Hoxc-8 and Hoxd-4, but not by a divergent homeobox gene, indicates that the capacity to regulate cartilage differentiation is specific to homeobox genes of the Hox subclass.
A similar phenotype is found in Hoxd-4 transgenic mice ( [ 1 ] and Kappen, manuscript in preparation) indicating that Hox transcription factors regulate chondrocyte development.