Example sentences for: hox

How can you use “hox” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Besides the 18S rRNA evidence, other genetic evidence for the grouping of nematodes and arthropods has come from qualitative interpretations of Hox gene [ 10 ] and β-thymosin [ 12 ] evolution.

  • In the case of Hox genes, support comes from a single posterior gene sequence (Y75B8A.

  • We found the expression of p107 mRNA and Bmp-4 mRNA to be decreased, which, if reflected in reduced protein levels, would be consistent with the phenotype of delayed cartilage maturation in Hox transgenic animals: As Bmp-4 was shown to have a positive effect on hypertrophy and inhibitory effect on proliferation [ 37 38 ] , decreased Bmp-4 expression would be expected to promote chondrocyte proliferation.

  • We found a similar phenotype upon overexpression of Hoxd-4 in our transgenic system (Kappen, manuscript in preparation), whereas overexpression of the LIM-homeodomain transcription factor Isl-1 did not cause abnormalities in cartilage but other developmental defects [ 1 9 ] . The observation that cartilage is affected by misregulation of Hoxc-8 and Hoxd-4, but not by a divergent homeobox gene, indicates that the capacity to regulate cartilage differentiation is specific to homeobox genes of the Hox subclass.

  • Whether the elevated Ihh mRNA levels originate from increased expression in cells that make Ihh normally (prehypertrophic and hypertrophic chondrocytes) or from ectopic activation by the Hox transcription factors in proliferating cells, remains to be investigated.


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