Example sentences for: hox

How can you use “hox” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • One difficulty with interpreting such qualitative evidence, including Hox gene orthology, is that almost any pattern can be found in nature if one looks.

  • By extending the collection of candidate genes, or screening on microarrays, it may thus be possible to identify specific targets for Hox transcription factors in chondrocytes.

  • We found a similar phenotype upon overexpression of Hoxd-4 in our transgenic system (Kappen, manuscript in preparation), whereas overexpression of the LIM-homeodomain transcription factor Isl-1 did not cause abnormalities in cartilage but other developmental defects [ 1 9 ] . The observation that cartilage is affected by misregulation of Hoxc-8 and Hoxd-4, but not by a divergent homeobox gene, indicates that the capacity to regulate cartilage differentiation is specific to homeobox genes of the Hox subclass.

  • This has important implications for the identification of the transcriptional targets of Hox transcription factors.

  • In summary, the gene expression profiles of primary chondrocytes from Hoxc-8 transgenic animals display notable differences in the expression of regulators of chondrocyte maturation in a pattern largely consistent with delayed chondrocyte maturation in vivo . These results now allow us to investigate whether any of these molecules is directly regulated by Hox transcription factors in chondrocytes.


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