Words similar to homozygotes
Example sentences for: homozygotes
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Specifically, population heterozygote advantage may be observed when resistance is additive (heterozygotes have risks equal to the average of the risks of the corresponding homozygotes), when resistance is recessive, or even when it is underdominant (heterozygotes have higher risk of disease than either corresponding homozygote).
There have been no studies (to our knowledge) in humans that directly compare the infectious disease outcomes of heterozygotes to those of homozygotes for the same alleles (interestingly, the situation is very different for autoimmune diseases; see DISCUSSION for further consideration).
Doherty and Zinkernagel [ 20 ] demonstrated using congenic mice that MHC homozygotes had more vigorous immune responses to lymphocytic choriomeningitis virus (LCMV) than the corresponding homozygotes, but since the pathology of the infection they used is due to the immune response, the enhanced immune response actually resulted in reduced survival.
There is also an interval of approximately 2.5 cM that is apparently maintained in heterozygosity in AXB21 on chromosome 2. Such maintenance should be accompanied by reduced fecundity in this line if homozygotes are lethal or sublethal.
In heterozygous infants with the WT/ΔF508 genotype, sweat chloride excretion is elevated 1.5-fold over normal values compared to a tenfold increase in homozygous patients with the ΔF508/ΔF508 genotype [ 32 ] . Adult heterozygous patients have fewer problems with respiratory infections compared to homozygotes [ 5 ] . Our findings that bile acid absorption was moderately increased in heterozygotes and markedly increased in homozygotes were therefore not unexpected.