Words similar to homozygotes
Example sentences for: homozygotes
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In several countries in northwestern Europe, however, the percentage of C282Y homozygotes in hemochromatosis case series is greater than 90% [ 33 34 35 37 38 ] . In Queensland, a frequency of C282Y homozygosity of 100% was reported among patients identified by phenotype criteria [ 42 ] . Thus, the selection criterion of C282Y homozygosity in the present study nonetheless resulted in a group of hemochromatosis probands the HFE genotypes of which are similar to those of hemochromatosis patients of northwestern European descent in other studies.
ΔF508 heterozygotes are affected to a lesser degree than are homozygotes.
Of the two ways described above in which MHC genotype may affect disease outcome, the first - association between a particular allele and disease outcome - has been repeatedly documented in human populations by various methods of genetic epidemiology [ 17 ] . The second kind of effect, more vigorous immune responses to a pathogen by a heterozygote as compared to homozygotes for the same alleles, which we term "allele-specific overdominance," has been suggested by several animal studies [ 18 19 20 21 ] , although none of these studies is unambiguous (see DISCUSSION).
Because of this confounding, under some parameter values, population heterozygote advantage can occur even when heterozygotes are not at an advantage relative to their corresponding homozygotes.
, a residual of -116,000; n = 12), the AB heterozygotes have an average of -8,000 neurons ( n = 18), and the BB homozygotes have an average of 290,000 neurons ( n = 6).