Words similar to homozygotes
Example sentences for: homozygotes
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Moreover, direct estimates of the allele-specific effects of heterozygosity (relative to the corresponding homozygotes), nearly absent in the infectious disease-HLA literature, are frequently found in studies of HLA genotype and chronic (mostly autoimmune) diseases [ 28 29 30 ] . We do not know the reason for this difference in approach, but suspect that some infectious disease investigators, informed by the evolutionary hypothesis of overdominance for infectious disease resistance and by animal studies, may have a special interest in detecting effects of heterozygosity per se . Many studies of HLA-autoimmune disease associations, on the other hand, seem to focus more on the effects of individual alleles and, having established these, move on to investigate the dependence of these effects on genetic modifiers, including the identity of the individual's other allele at the same locus.
Prior to use for Western blotting, brush border membrane vesicle suspensions were tested for enrichment of brush border enzymes and showed a 4 - 5-fold increase of alkaline phosphatase and a 10 - 11-fold increase in alpha-glucosidase activity using standard methods [ 19 ] . On densitometric evaluations of Western blots, IBAT concentrations were twice as high in heterozygotes as in controls (17 ± 3 vs. 5 ± 1 density units; p < 0.05) and four times as high in homozygotes (30 ± 4 vs. 5 ± 1 density units; p < 0.05) (Fig.
Figure 1shows the parameter regions in which population heterozygote advantage is expected and those in which the contrary is expected: homozygotes on average are more likely to have a favorable disease course.
In the absence of heat shock, slimb homozygotes exhibited the early lethality of slimb mutants, but a single 30 minute heat shock at 37°C during first instar was enough to allow some larvae to reach the wandering third instar stage 4 days later.
In order to perform genotype by network score associations, biallelic loci were assigned a '1' for A/A homozygotes, a '2' for A/B heterozygotes and a '3' for B/B heterozygotes.
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