Words similar to homozygosity
Example sentences for: homozygosity
How can you use “homozygosity” in a sentence? Here are some example sentences to help you improve your vocabulary:
The first three tumor cell lines had known losses in specific chromosomal regions, and the fourth had loss of homozygosity of the PTEN gene.
We selected only probands who had a hemochromatosis phenotype and C282Y homozygosity.
Taken together, these observations could explain the occurrence of CVID or IgGSD and hemochromatosis due to HFE C282Y homozygosity in some of the present index patients [ 26 ] and account for the occurrence of IgA deficiency and hemochromatosis in different members of the same family [ 27 ] .
The generation of Hoxc-8 transgenic mice and the characterization of their phenotype have been published [ 1 ] . Briefly, Hoxc-8 expressing mice are generated in a binary transgenic mouse system [ 44 ] by crossing a transactivator strain (harboring a transgene in which expression of the transcriptional transactivator VP16 is under control of the Hoxc-8 promoter; [ 45 ] ) to a transresponder strain (that carries as a transgene the Hoxc-8 cDNA linked to the ICP4 immediate early gene promoter, which is silent in mice in the absence of VP16; [ 45 46 ] ). Upon combination of both transgenes, the Hoxc-8 transresponder transgene is activated, and Hoxc-8 becomes overexpressed [ 23 ] . This system also allows the generation of transgenic mice with increased gene dosage by superimposition of transgene loci to homozygosity [ 23 44 ] . For the studies reported here, we used the T239 transactivator and the IE-c8-254 transresponder strains.
In North America, phenotype frequencies of HLA alleles in persons with hemochromatosis and in control populations have been reported from Canada, Utah, and Minnesota [ 17 18 19 ] . HLA haplotype frequencies for hemochromatosis patients and control subjects in North America have been reported only from Utah [ 20 ] . The purpose of the present work was to quantify and analyze the frequencies of HLA-A and -B alleles and haplotypes in hemochromatosis probands with C282Y homozygosity in central Alabama, and to compare the present results to those reported in other populations.
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