Words similar to homozygosity
Example sentences for: homozygosity
How can you use “homozygosity” in a sentence? Here are some example sentences to help you improve your vocabulary:
Eight of the present index patients (3 CVID, 5 IgGSD; 2 men, 6 women) also had hemochromatosis associated with homozygosity for
Homozygosity for a particular Pgm allele was confirmed by starch-gel electrophoresis assay, as previously described ([ 32] and data not shown).
The generation of Hoxc-8 transgenic mice and the characterization of their phenotype have been published [ 1 ] . Briefly, Hoxc-8 expressing mice are generated in a binary transgenic mouse system [ 44 ] by crossing a transactivator strain (harboring a transgene in which expression of the transcriptional transactivator VP16 is under control of the Hoxc-8 promoter; [ 45 ] ) to a transresponder strain (that carries as a transgene the Hoxc-8 cDNA linked to the ICP4 immediate early gene promoter, which is silent in mice in the absence of VP16; [ 45 46 ] ). Upon combination of both transgenes, the Hoxc-8 transresponder transgene is activated, and Hoxc-8 becomes overexpressed [ 23 ] . This system also allows the generation of transgenic mice with increased gene dosage by superimposition of transgene loci to homozygosity [ 23 44 ] . For the studies reported here, we used the T239 transactivator and the IE-c8-254 transresponder strains.
Sickle cell anemia (Hb SS) results from homozygosity for a A→T substitution at codon 6 of the β-globin gene (GAG→GTG) leading to a glutamic acid to valine (Glu→Val) substitution in the β globin chain of human adult hemoglobin.
We selected only probands who had a hemochromatosis phenotype and C282Y homozygosity.
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