Example sentences for: homodimerization

How can you use “homodimerization” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • IL-6 signals through a set of signaling proteins of the JAK and STAT kinase families [ 14 ] . The JAK and STAT kinases are activated by phosphorylation initiated by the homodimerization of the IL-6/IL-6 receptor complex on the cell surface.

  • The major IL-6 signaling intermediates are JAK2 and STAT3 [ 15 ] . Homodimerization of the IL-6/receptor complex induces the autophosphorylation of JAK2.

  • The BTB domain is a highly conserved 120 amino acid, hydrophobic-rich, protein-protein interaction domain that mediates homodimerization and heterodimerization of a large number of proteins with diverse functions [ 9 ] . The three dimensional structure of one BTB domain [ 33 ] has been characterized through structure-function studies [ 34 ] . Proteins containing BTB domains are currently categorized into three groups [ 35 ] : 1) DNA-binding proteins often containing zinc fingers in the C-terminal region, 2) actin binding proteins that contain a kelch repeat of ~50 residues that terminate in a pair of glycine residues [ 36 ] and 3) proteins that have neither an actin-binding domain nor a DNA-binding domain.


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