Words similar to homodimeric
Example sentences for: homodimeric
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VEGF is a 45 kDA heparin-binding homodimeric glycoprotein with a predominant specificity to vascular endothelial cells [ 4 5 6 7 ] . Recent investigations demonstrate that VEGF increases vascular permeability [ 4 ] , endothelial cell proliferation in vitro [ 8 ] , and angiogenesis in vivo [ 9 ] . We have previously demonstrated that VEGF mRNA is upregulated in rat gastrocnemius muscle following 1 hour of acute submaximal treadmill exercise [ 10 ] , in dog gastrocnemius muscle following 1 hour of electrical stimulation [ 11 ] , and in human vastus lateralis following 30 min of one-legged knee extension exercise at 50% maximal capacity [ 12 ] . Other studies show similar upregulation of VEGF mRNA in chronically electrically stimulated rat skeletal muscle [ 13 14 ] , and in human vastus lateralis following 45 min of one-legged knee extension exercise [ 15 ] .
VEGF-A is the prototypic member of a family of secreted, homodimeric glycoproteins with endothelial cell-specific mitogenic activity and the ability to stimulate angiogenesis in vivo [ 2].
The isolated E. coli RNase III catalytic domain, which retains homodimeric behavior, can cleave dsRNA substrates under specific conditions in vitro [ 11 ] . The recently reported crystal structure of the catalytic domain of Aquifex aeolicus RNase III reveals an extensive subunit interface, with the cleft between the subunits predicted to bind dsRNA [ 12 ] . The two proposed active sites are positioned at each end of the intersubunit cleft and contain conserved residues from each subunit.
S. pombe RNA triphosphatase Pct1 is a 303-amino acid polypeptide with a homodimeric quaternary structure [ 12 ] . The pct1 +gene contains a single intron within the open reading frame [ 12 ] . S. pombe RNA guanylyltransferase Pce1 is a 402-amino acid monomeric protein [ 20 ] ; there are no introns within the pce1 +gene.
The homodimeric transmembrane glycoprotein CD 105 (endoglin) is relatively specific for endothelial cells and is abundant with more than 500,000 copies per cell on HUVEC [ 24 ] . It is not clear, however, why they are CD59-positive MP that express CD105 and some that do not (Fig.
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