Words similar to homodimeric
Example sentences for: homodimeric
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VEGF-A is the prototypic member of a family of secreted, homodimeric glycoproteins with endothelial cell-specific mitogenic activity and the ability to stimulate angiogenesis in vivo [ 2].
VEGF is a 45 kDA heparin-binding homodimeric glycoprotein with a predominant specificity to vascular endothelial cells [ 4 5 6 7 ] . Recent investigations demonstrate that VEGF increases vascular permeability [ 4 ] , endothelial cell proliferation in vitro [ 8 ] , and angiogenesis in vivo [ 9 ] . We have previously demonstrated that VEGF mRNA is upregulated in rat gastrocnemius muscle following 1 hour of acute submaximal treadmill exercise [ 10 ] , in dog gastrocnemius muscle following 1 hour of electrical stimulation [ 11 ] , and in human vastus lateralis following 30 min of one-legged knee extension exercise at 50% maximal capacity [ 12 ] . Other studies show similar upregulation of VEGF mRNA in chronically electrically stimulated rat skeletal muscle [ 13 14 ] , and in human vastus lateralis following 45 min of one-legged knee extension exercise [ 15 ] .
The isolated E. coli RNase III catalytic domain, which retains homodimeric behavior, can cleave dsRNA substrates under specific conditions in vitro [ 11 ] . The recently reported crystal structure of the catalytic domain of Aquifex aeolicus RNase III reveals an extensive subunit interface, with the cleft between the subunits predicted to bind dsRNA [ 12 ] . The two proposed active sites are positioned at each end of the intersubunit cleft and contain conserved residues from each subunit.
The homodimeric transmembrane glycoprotein CD 105 (endoglin) is relatively specific for endothelial cells and is abundant with more than 500,000 copies per cell on HUVEC [ 24 ] . It is not clear, however, why they are CD59-positive MP that express CD105 and some that do not (Fig.
S. pombe RNA triphosphatase Pct1 is a 303-amino acid polypeptide with a homodimeric quaternary structure [ 12 ] . The pct1 +gene contains a single intron within the open reading frame [ 12 ] . S. pombe RNA guanylyltransferase Pce1 is a 402-amino acid monomeric protein [ 20 ] ; there are no introns within the pce1 +gene.
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