Words similar to homodimers
Example sentences for: homodimers
How can you use “homodimers” in a sentence? Here are some example sentences to help you improve your vocabulary:
However, time 0 and early and late trophoblast cultures derived from the same placenta (lanes 9-11) showed additional high molecular weight LHR variants (~170 kDa), possibly LHR homodimers [ 19 ] , which were barely detectable or undetectable in other tissues, including placental CV.
For example, it is possible that the inhibitory effect of LG1069 in the stable CAR expressing cell line is based on the sequestration of limiting amounts of RXR into ligand-dependent homodimers, as has been suggested in previous studies using primary hepatocytes [ 17 ] . However, similar effects were observed with the relatively large amounts of RXR used for the biochemical studies or with the transient transfections, which relied on cotransfected RXR.
On the other hand, each of the mutations is about as defective in heterodimers with T91I as it is in each of the Thr59 mutant homodimers.
This positive response to 9-cis-RA contrasts with the inhibition that would result from the loss of RXR to ligand-dependent homodimers [ 20 ] , confirming that these studies reflect the activity of CAR/RXR heterodimers and demonstrating that such complexes can be permissive for RXR signaling.
NAC is an antioxidant thiol that raises the intracellular pool of glutathione the major redox regulating mechanism in the A549 epithelial cell line [ 45 ] . Interestingly, it has been reported that NAC can have differential effects on NF-κB binding activity suggesting only a subset of NF-κB binding complexes are redox sensitive [ 58 ] . Moreover, it has been shown that NAC inhibits Rel A/p50 heterodimers but not p50 homodimers and can inhibit NF-κB binding to only certain variant κB elements which presumably interact with distinct redox sensitive NF-κB binding complexes [ 59 ] . These observations are consistent with our findings that indicate NAC predominantly inhibits Rel A homodimers since that was the major NF-κB subunit induced by RSV infection of A549 cells.
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