Words similar to hnscc

Example sentences for: hnscc

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Only patients with previously untreated HNSCC were included in this study.
, showing the highest levels of chromosomal sensitivity in lymphocytes after exposure to the clastogen bleomycin in HNSCC patients who were non-smokers [ 7 ] . Relatively few studies have directly investigated the impact of tobacco/alcohol exposure on the genetic composition of HNSCC.
These results are congruent with those reported in the literature for CGH analysis of HNSCC [ 11 12 13 14 ] . The level of genomic instability, measured by the median number of continuous copy number changes by CGH analysis was also not influenced by the severity of carcinogen exposure.
Tumor samples from patients undergoing curative treatment for HNSCC were obtained at time of biopsy or surgical resection in the operating room, following guidelines established by the Institutional Review Board.
Amplification and expression of cyclin D1, p53 mutation and deletions of 3p, 5q, and 9p21 are suggested to be influenced by the degree of tobacco exposure [ 4 6 8 ] . The largest effort on this topic has been reported by Koch and colleagues, who found significantly higher rates of p53 mutation and loss of heterozygosity at 3p, 4q, and 11q as part of allelotyping analysis of 10 individual loci [ 4 ] . No studies have utilized true genome-wide evaluative measures to analyze the impact of carcinogen exposure on the accumulated chromosomal abnormalities in HNSCC.