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Example sentences for: hnscc

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Comparative genomic hybridization (CGH), originally described by Kallionemi in 1992, is an ideal screening measure, allowing the simultaneous detection of gains, losses and amplifications in genetic information in an individual tumor [ 9 ] . In addition, several authors have used the total number of chromosomal abnormalities as an assessment of genomic instability [ 10 ] . In this study, CGH analysis showed the presence of significant overlap in genomic instability and in the individual chromosomal abnormalities based on the degree of tobacco/alcohol exposure in HNSCC, with the exception of gains/amplifications at 3q and 1p.
Taking the limitations into account, we identified no differences in the degree of chromosomal instability and significant overlap in the pattern of chromosomal aberrations occurring in patients with HNSCC divided by the severity of tobacco/alcohol exposure.
Tumor samples from patients undergoing curative treatment for HNSCC were obtained at time of biopsy or surgical resection in the operating room, following guidelines established by the Institutional Review Board.
Only patients with previously untreated HNSCC were included in this study.
These results are congruent with those reported in the literature for CGH analysis of HNSCC [ 11 12 13 14 ] . The level of genomic instability, measured by the median number of continuous copy number changes by CGH analysis was also not influenced by the severity of carcinogen exposure.