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Example sentences for: hnoba

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All versions of the HNOBA domain, except one from Rhodobacter sphaeroides , contain a conserved histidine between the core region and the long C-terminal α-helix that links it to a kinase or cyclase domain (Fig.
Given that these cyanobacterial HNOB proteins are also the closest bacterial relatives of the animal HNOB domains, it appears likely that the animal lineage acquired a related assemblage of HNOB and HNOBA domain as a single piece.
Thus, the HNOB and HNOBA domains resemble functionally similar CACHE and CHASE domains, which have also been acquired by certain eukaryotic lineages via lateral transfer from bacteria [ 14 36 37 ] . A phylogenetic analysis of the guanylyl cyclase domains of the animal SGCs shows that their closest relatives are cyclases from various bacteria such cyanobacteria, and Leptospira (data not shown).
Evolutionary history, domain architectures, and gene neighborhoods of the HNOB and HNOBA domain proteins
The co-occurrence of the HNOB and the HNOBA domains in either the same protein or proteins encoded by the same operon suggests a strong functional interaction between them.