Words similar to hnoba

Example sentences for: hnoba

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Identification of the HNOB and HNOBA domains could help in further investigations of the SGCs that are critical components of the nitric oxide signaling pathway in animals.
This may suggest the possibility of the HNOBA domain binding some, as yet unknown, endogenous ligand.
Interestingly, binding studies on a synthetic pyrazolopyridine SGC agonist, BAY 41-2272 have suggested a role for the region 236-290 of the human SGC1 α-subunit in interacting with this ligand [ 25 26 ] . Though actual cross-linking occurred with cysteine residues situated just N-terminal to the HNOBA domain, it is likely that the rest of domain is involved in contact with the ligand.
The HNOB and HNOBA domains are likely to function synergistically or cooperatively.
Thus, the HNOB and HNOBA domains resemble functionally similar CACHE and CHASE domains, which have also been acquired by certain eukaryotic lineages via lateral transfer from bacteria [ 14 36 37 ] . A phylogenetic analysis of the guanylyl cyclase domains of the animal SGCs shows that their closest relatives are cyclases from various bacteria such cyanobacteria, and Leptospira (data not shown).