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Example sentences for: hnoba

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The co-occurrence of the HNOB and the HNOBA domains in either the same protein or proteins encoded by the same operon suggests a strong functional interaction between them.
Because the middle domain of the SGCs is always associated with the HNOB domains (see below), we named it the HNOBA ( HNOB A ssociated) domain.
Interestingly, binding studies on a synthetic pyrazolopyridine SGC agonist, BAY 41-2272 have suggested a role for the region 236-290 of the human SGC1 α-subunit in interacting with this ligand [ 25 26 ] . Though actual cross-linking occurred with cysteine residues situated just N-terminal to the HNOBA domain, it is likely that the rest of domain is involved in contact with the ligand.
Identification of the HNOB and HNOBA domains could help in further investigations of the SGCs that are critical components of the nitric oxide signaling pathway in animals.
Thus, the HNOB and HNOBA domains resemble functionally similar CACHE and CHASE domains, which have also been acquired by certain eukaryotic lineages via lateral transfer from bacteria [ 14 36 37 ] . A phylogenetic analysis of the guanylyl cyclase domains of the animal SGCs shows that their closest relatives are cyclases from various bacteria such cyanobacteria, and Leptospira (data not shown).