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Example sentences for: hnoba

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Identification of the HNOB and HNOBA domains could help in further investigations of the SGCs that are critical components of the nitric oxide signaling pathway in animals.
Interestingly, binding studies on a synthetic pyrazolopyridine SGC agonist, BAY 41-2272 have suggested a role for the region 236-290 of the human SGC1 α-subunit in interacting with this ligand [ 25 26 ] . Though actual cross-linking occurred with cysteine residues situated just N-terminal to the HNOBA domain, it is likely that the rest of domain is involved in contact with the ligand.
Interestingly, the histidine kinases from the two cyanobacteria, and the GGDEF domain protein from Rhodobacter , which co-occur with solo HNOB domain proteins contain HNOBA domains at their extreme N-terminus (Fig.
All versions of the HNOBA domain, except one from Rhodobacter sphaeroides , contain a conserved histidine between the core region and the long C-terminal α-helix that links it to a kinase or cyclase domain (Fig.
Because the middle domain of the SGCs is always associated with the HNOB domains (see below), we named it the HNOBA ( HNOB A ssociated) domain.