Words similar to hla
Example sentences for: hla
How can you use “hla” in a sentence? Here are some example sentences to help you improve your vocabulary:
HLA typing
Power/type 2 error appears to be a major factor—if the genetic effect is sufficiently large ( HLA in Type 1 diabetes mellitus or CFH in age-related macular degeneration)—or, if the sample size is large, then there appears to be a greater chance of “hard” replication.
Author 1 (JCB) conceived the study, and contributed CVID and IgGSD index cases, case characterization, and HLA typing, tabulated index case HLA frequency values, performed statistical comparisons, and formulated the manuscript.
Epidemiologically, HLA genotype partially accounts for inter-patient variation in disease severity or progression rates for such long-term viral infections as HIV, human T-cell lymphotropic virus, type 1 (HTLV-1), and hepatitis B and C [ 5 6 7 8 9 ] . Such associations can lead to mechanistic studies to test hypotheses about the immunologic basis of these associations [ 10 11 ] and could, in principle, be used to help predict individual prognoses [ 12 13 ] . At least one clinical study has shown that HLA genotype affects the immune response to a candidate HIV vaccine [ 14 ] . Vaccine designers have begun to take account of the HLA genotypes of potential recipients in choosing antigens for inclusion in a vaccine [ 15 ] , and it has been suggested that HLA genotype be considered in designing samples for inclusion in epidemiologic studies of anti-HIV immune response [ 12 ] . In evolutionary biology, the possibility that HLA heterozygotes are more resistant to infectious diseases is the basis for a leading hypothesis to explain the unparalleled diversity of HLA genes (and MHC genes in other vertebrates) and the maintenance of this diversity over long periods of evolutionary time [ 16 ] .
In principle, the same problem could occur in any study of HLA associations with disease outcome.
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