Words similar to hla
Example sentences for: hla
How can you use “hla” in a sentence? Here are some example sentences to help you improve your vocabulary:
The estimated prevalence of CVID and IgGSD in central Alabama could be reasonably attributed to the fact that many HLA haplotypes significantly associated with these disorders are also common in the general population.
This HLA type occurs among 60% of patients with autoimmune disease and antibodies to U1-70 kD, but its prevalence in the normal healthy individuals is only about 25% [ 16 30 ] . Hence, if the association between HLA DR4 and the presence of antibodies to U1-70 kD exists for healthy individuals and if, due to selection bias, our population contained very few (<4%) DR4-positive individuals and the population of Newkirk et al . contained a very high (≥ 50%) prevalence of DR4-positive subjects, this could account for the observed differences.
HLA -A and -B alleles were detected using low-resolution DNA-based typing (PCR/sequence-specific oligonucleotide probe) in index cases [ 16 ] . Control subjects were tested using the microdroplet lymphocytotoxicity test [ 8 ] ; subjects were evaluated using antisera that detected allele assignments described in the 9 thInternational Histocompatibility Workshop [ 17 ] . Because the levels of resolution of the DNA-based and serological typing methods we used are similar, alleles detected by these respective methods provide concordant allele assignments, with the exception of B*70 and B*71 that were not detected by serological methods.
Modification of the ancestral chromosome by recombination and admixture as a result of geographic migration could explain the previously undescribed occurrence of HLA haplotypes that occur in association with C282Y.
Power/type 2 error appears to be a major factor—if the genetic effect is sufficiently large ( HLA in Type 1 diabetes mellitus or CFH in age-related macular degeneration)—or, if the sample size is large, then there appears to be a greater chance of “hard” replication.
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