Example sentences for: histones

How can you use “histones” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • As SAHA treatment increased histone (H3 and H4) protein and acetylation levels in both cell lines, this may have altered the association of histones with DNA, thereby altering nucleosomal conformation and stability [ 27, 44].

  • The proper assembly of basic proteins with nucleic acids, such as occurs in the packaging of histones with DNA to produce chromatin and in the packaging of ribosomal proteins with rRNA to form ribosomes, is a reaction that must be facilitated so as to prevent the aggregation of these oppositely charged groups of molecules.

  • Microarray-based genome mapping protocols utilize the technique of chromatin immunoprecipitation (ChIP) to isolate genomic DNA associated in vivo with a transcription factor of interest, or with histones exhibiting a particular post-translational modification.

  • Changes in the acetylation or phosphorylation of histones result in alterations that can be visualized as changes in protein mobility on an acid-urea gel following western blot analysis [ 26, 27].

  • Deacetylation of core histones then alters chromatin structure and results in transcriptional repression [ 13 14 ] .


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