Words similar to histone
Example sentences for: histone
How can you use “histone” in a sentence? Here are some example sentences to help you improve your vocabulary:
It was reported that some agents, e.g. histone deacetylase inhibitors [ 14 ] or DNA methylation inhibitors [ 15 ] , can rescue the IFNg inducibility of MHCII in cultured tumor cells.
These results suggested that SAHA not only increased histone acetylation, as shown in H4 (Fig.
The role of the coactivators could be just as bridging factors, although some of the members of the p160 family and CBP/p300 present histone acetyltransferase activity [ 34 35 ] . Stat3 is a member of the JAK/STAT signaling pathway, which is a transcription factor itself that after activation binds to specific sequences in DNA to regulate expression of genes related to proliferation, differentiation and cell survival.
Similar observations were obtained for other gene clusters, including amylases on 1p21, annexins on 4q21, homeobox proteins on 7p15 and 17q21, metallothioneins on 16q13, crystalline proteins on 2q33, glutathione- S -transferases (m1, m2, m3, m4 and m5) on 1p13, histone families (H2A/H2B/H3/H4) on 6p21, killer cell lectin-like receptors on 12p13, proline-rich proteins on 12p13, protocadherins on 5p15, s100 calcium-binding proteins on 1q21, keratins on 17q12, ADP-ribosylation factors (3, 4 and 5) on 10q22, and the major histocompatibility complex on 6p21.
The transcriptional regulatory activities of Smad1 in the nucleus are associated with its ability to directly bind to DNA [ 12 ] , its interaction with other DNA-binding transcription factors, such as OAZ, SIP1 and Hoxc-8 [ 13 14 15 ] , and also its interaction with the master transcriptional co-activator CBP/p300 [ 16 ] . Smad4 is an essential functional partner in Smad-regulated transcription and also interacts with CBP/p300 via a domain within the central linker region named as SAD (Smad Activation Domain) [ 13 ] . Since CBP/p300 has intrinsic histone acetyltransferase (HAT) activity and participates in chromatin remodeling, the recruitment of CBP/p300 into the DNA-binding complexes of Smad1 and Smad4 is likely a critical step in Smad-regulated gene activation.
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