Words similar to histone
Example sentences for: histone
How can you use “histone” in a sentence? Here are some example sentences to help you improve your vocabulary:
These isoforms can be identified by their characteristic mobility and by staining with antibodies specific to each histone isoform [ 26].
However, the activity of PP5 against histone (865 +/- 31 nMoles Pi/min/mg protein) is less than that of PP2A.
The beads with the bound proteins were washed and then resuspended in 30 μl of kinase buffer [50 mM HEPES, pH 7.4, 2.5 mM EGTA, 10 mM β-glycerophosphate, 0.1 mM vanadate, 1 mM NaF, 1 mM DTT, 10 mM MgCl 2 , 20 μM ATP, 50 μCi γ- 32P-ATP (7000 Ci/mmol, ICN), and 1 μg histone H1].
It has been demonstrated that malignant tissues with accelerated cell cycle show higher levels of ProTα expression than normal or surrounding healthy tissues [ 67 ] . ProTα was shown as a marker for breast cancer [ 68 ] , hepatocarcinoma [ 69 ] , and plasma levels of its derivative Tα 1 been proposed as a marker for the prognosis of lung cancer [ 70 ] . In ligand blotting assays, ProTα bound only to chromatin pools and nuclear fractions where histone H1 was present [ 71 72 ] . The analysis of the interaction of ProTα with H1-containing chromatin suggests a putative role for ProTα in the fine-tuning of the stoichiometry and/or mode of interaction of H1 with chromatin [ 73 ] . Interestingly, HL-60 cells overexpressing ProTα show an enhancement of accessibility of micrococcal nuclease to chromatin, implying relaxed chromatin structure for enhanced cell cycle gene expression [ 74 ] .
The recent findings that members of the several different families of coactivators possess intrinsic histone acetyltransferase activity suggests that activated SHRs, and nuclear receptors in general, may also recruit these cofactors to remodel chromatin structure for better accessibility of the transcriptional machinery to DNA [ 5 6 ] .
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