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Example sentences for: hgfa

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HGF/SF is synthesized as a pro-HGF, and once activated by the HGF activator (HGFA), the complex HGF/SF-Met affects numerous normal cellular processes [ 22 ] . HGF/SF-Met is also involved in malignant transformation, presumably as a mediator in interaction between tumor and stroma, which enhances tumor progression, and also angiogenesis [ 23 34 ] . In invasive ductal carcinoma, stronger expression of HGF/SF seems to be associated with tubule formation [ 25 ] . HGF/SF is overexpressed in breast carcinoma in situ and invasive ductal carcinoma in comparison with normal breast tissue.
The activation of HGF/SF by HGFA might be modified by the two HGFA inhibitors, HAI-1 and HAI-2.
ER = estrogen receptor; HGFA = hepatocyte growth factor activator; HGF/SF = hepatocyte growth factor/scatter factor; PR = progesterone receptor; RT-PCR = reverse transcriptase-polymerase chain reaction.
Highly invasive breast cancer cells express large amounts of HGF and Met, and no HAI-1, whereas breast cancer cells with low invasive potential have low levels of HGF and Met, and high levels of HAI-1 [ 22 ] . In a mouse model system HGF antagonists suppressed the conversion of pancreatic tumors from carcinoma in situ into invasive cancer [ 23 ] . It seems that regulation of the HGF/SF stimulation and inhibition activities is associated with the metastatic potential of tumor cells, and knowing the status of HGFA, HAI-1 and HAI-2, in addition to Met, might provide useful information.