Example sentences for: hgf
How can you use “hgf” in a sentence? Here are some example sentences to help you improve your vocabulary:
The significance of HGF/SF as a marker of poor prognosis might also be associated with its effects on acquired resistance to anti-cancer drugs [ 35 36 ] . HGF/SF protects cancer cells from DNA-damaging chemotherapy agents through pathways involving signaling from Met to phosphoinositide 3-kinase and c-Akt [ 29 ] . Human breast cancer cells, preincubated with HGF/SF and then exposed to Adriamycin, exhibit an altered pattern of gene expression compared with cells treated with Adriamycin alone.
The activation of HGF/SF by HGFA might be modified by the two HGFA inhibitors, HAI-1 and HAI-2.
HGF/SF is synthesized as a pro-HGF, and once activated by the HGF activator (HGFA), the complex HGF/SF-Met affects numerous normal cellular processes [ 22 ] . HGF/SF-Met is also involved in malignant transformation, presumably as a mediator in interaction between tumor and stroma, which enhances tumor progression, and also angiogenesis [ 23 34 ] . In invasive ductal carcinoma, stronger expression of HGF/SF seems to be associated with tubule formation [ 25 ] . HGF/SF is overexpressed in breast carcinoma in situ and invasive ductal carcinoma in comparison with normal breast tissue.
This finding suggests that the expression of these proteins in breast cancer is regulated by soluble factors produced by the tumor cells [ 26 27 ] . High levels of expression of HGF and Met are associated with invasive breast cancer, and might be causally linked to early recurrences, metastatic disease and shortened survival of breast cancer patients [ 28 29 ] . High levels of HGF/SF detected within breast tumor extracts are correlated with larger tumor size and shorter relapse-free and overall survival compared with tumors with low HGF/SF concentration [ 30 ] .
The presence of Met-HGF/SF and β-actin were assessed in the fluid, which was collected during the second postoperative day because during the first 24 hours it might contain many erythrocytes and debris.
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