Example sentences for: hgf
How can you use “hgf” in a sentence? Here are some example sentences to help you improve your vocabulary:
The significance of HGF/SF as a marker of poor prognosis might also be associated with its effects on acquired resistance to anti-cancer drugs [ 35 36 ] . HGF/SF protects cancer cells from DNA-damaging chemotherapy agents through pathways involving signaling from Met to phosphoinositide 3-kinase and c-Akt [ 29 ] . Human breast cancer cells, preincubated with HGF/SF and then exposed to Adriamycin, exhibit an altered pattern of gene expression compared with cells treated with Adriamycin alone.
ER = estrogen receptor; HGFA = hepatocyte growth factor activator; HGF/SF = hepatocyte growth factor/scatter factor; PR = progesterone receptor; RT-PCR = reverse transcriptase-polymerase chain reaction.
Highly invasive breast cancer cells express large amounts of HGF and Met, and no HAI-1, whereas breast cancer cells with low invasive potential have low levels of HGF and Met, and high levels of HAI-1 [ 22 ] . In a mouse model system HGF antagonists suppressed the conversion of pancreatic tumors from carcinoma in situ into invasive cancer [ 23 ] . It seems that regulation of the HGF/SF stimulation and inhibition activities is associated with the metastatic potential of tumor cells, and knowing the status of HGFA, HAI-1 and HAI-2, in addition to Met, might provide useful information.
HGF/SF and Met have been found in a variety of tumors [ 31 32 33 ] , and in lymph nodes of patients with no tumor [ 34 ] , but never in the fluid drained from the tumor bed or the lymph node basin.
We included only patients who underwent conserving breast surgery so that we could evaluate the correlations of Met-HGF/SF expression with both the tumor margins and the status of the axillary lymph nodes.
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