Example sentences for: hgf
How can you use “hgf” in a sentence? Here are some example sentences to help you improve your vocabulary:
Normal mammary ducts within infiltrating cancer showed intermediate levels of HGF/SF.
Cells treated with HGF/SF and Adriamycin also had modified cell line regulation and signal transduction that might suggest mechanisms by which HGF/SF exerts its protective activity [ 31 ] .
ER = estrogen receptor; HGFA = hepatocyte growth factor activator; HGF/SF = hepatocyte growth factor/scatter factor; PR = progesterone receptor; RT-PCR = reverse transcriptase-polymerase chain reaction.
HGF/SF is synthesized as a pro-HGF, and once activated by the HGF activator (HGFA), the complex HGF/SF-Met affects numerous normal cellular processes [ 22 ] . HGF/SF-Met is also involved in malignant transformation, presumably as a mediator in interaction between tumor and stroma, which enhances tumor progression, and also angiogenesis [ 23 34 ] . In invasive ductal carcinoma, stronger expression of HGF/SF seems to be associated with tubule formation [ 25 ] . HGF/SF is overexpressed in breast carcinoma in situ and invasive ductal carcinoma in comparison with normal breast tissue.
HGF/SF induces mitogenic and morphogenic changes, including rapid membrane ruffling, formation of microspikes, and increased cellular motility [ 12 13 ] . The diverse biological effects of HGF/SF are all mediated by Met, which is preferentially expressed on epithelial cells [ 14 ] . In vivo this receptor-ligand pair is essential for normal embryonic development [ 15 16 ] . Whereas Met signaling clearly has a role in normal cellular processes, this signaling pathway has also been implicated in tumor development and progression.
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