Example sentences for: hgf
How can you use “hgf” in a sentence? Here are some example sentences to help you improve your vocabulary:
This finding suggests that the expression of these proteins in breast cancer is regulated by soluble factors produced by the tumor cells [ 26 27 ] . High levels of expression of HGF and Met are associated with invasive breast cancer, and might be causally linked to early recurrences, metastatic disease and shortened survival of breast cancer patients [ 28 29 ] . High levels of HGF/SF detected within breast tumor extracts are correlated with larger tumor size and shorter relapse-free and overall survival compared with tumors with low HGF/SF concentration [ 30 ] .
We included only patients who underwent conserving breast surgery so that we could evaluate the correlations of Met-HGF/SF expression with both the tumor margins and the status of the axillary lymph nodes.
Highly invasive breast cancer cells express large amounts of HGF and Met, and no HAI-1, whereas breast cancer cells with low invasive potential have low levels of HGF and Met, and high levels of HAI-1 [ 22 ] . In a mouse model system HGF antagonists suppressed the conversion of pancreatic tumors from carcinoma in situ into invasive cancer [ 23 ] . It seems that regulation of the HGF/SF stimulation and inhibition activities is associated with the metastatic potential of tumor cells, and knowing the status of HGFA, HAI-1 and HAI-2, in addition to Met, might provide useful information.
vitronectin) [ 14 ] , and uPA as well as plasmin activate angiogenic factors such as VEGF, HGF, FGFs, and TGFβ [ 15 16 17 ] .
HGF/SF is synthesized as a pro-HGF, and once activated by the HGF activator (HGFA), the complex HGF/SF-Met affects numerous normal cellular processes [ 22 ] . HGF/SF-Met is also involved in malignant transformation, presumably as a mediator in interaction between tumor and stroma, which enhances tumor progression, and also angiogenesis [ 23 34 ] . In invasive ductal carcinoma, stronger expression of HGF/SF seems to be associated with tubule formation [ 25 ] . HGF/SF is overexpressed in breast carcinoma in situ and invasive ductal carcinoma in comparison with normal breast tissue.
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