Example sentences for: hgf
How can you use “hgf” in a sentence? Here are some example sentences to help you improve your vocabulary:
The presence of Met-HGF/SF and β-actin were assessed in the fluid, which was collected during the second postoperative day because during the first 24 hours it might contain many erythrocytes and debris.
Highly invasive breast cancer cells express large amounts of HGF and Met, and no HAI-1, whereas breast cancer cells with low invasive potential have low levels of HGF and Met, and high levels of HAI-1 [ 22 ] . In a mouse model system HGF antagonists suppressed the conversion of pancreatic tumors from carcinoma in situ into invasive cancer [ 23 ] . It seems that regulation of the HGF/SF stimulation and inhibition activities is associated with the metastatic potential of tumor cells, and knowing the status of HGFA, HAI-1 and HAI-2, in addition to Met, might provide useful information.
The activation of HGF/SF by HGFA might be modified by the two HGFA inhibitors, HAI-1 and HAI-2.
HGF/SF and Met have been found in a variety of tumors [ 31 32 33 ] , and in lymph nodes of patients with no tumor [ 34 ] , but never in the fluid drained from the tumor bed or the lymph node basin.
This finding suggests that the expression of these proteins in breast cancer is regulated by soluble factors produced by the tumor cells [ 26 27 ] . High levels of expression of HGF and Met are associated with invasive breast cancer, and might be causally linked to early recurrences, metastatic disease and shortened survival of breast cancer patients [ 28 29 ] . High levels of HGF/SF detected within breast tumor extracts are correlated with larger tumor size and shorter relapse-free and overall survival compared with tumors with low HGF/SF concentration [ 30 ] .
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