Example sentences for: hgf
How can you use “hgf” in a sentence? Here are some example sentences to help you improve your vocabulary:
HGF/SF induces mitogenic and morphogenic changes, including rapid membrane ruffling, formation of microspikes, and increased cellular motility [ 12 13 ] . The diverse biological effects of HGF/SF are all mediated by Met, which is preferentially expressed on epithelial cells [ 14 ] . In vivo this receptor-ligand pair is essential for normal embryonic development [ 15 16 ] . Whereas Met signaling clearly has a role in normal cellular processes, this signaling pathway has also been implicated in tumor development and progression.
Highly invasive breast cancer cells express large amounts of HGF and Met, and no HAI-1, whereas breast cancer cells with low invasive potential have low levels of HGF and Met, and high levels of HAI-1 [ 22 ] . In a mouse model system HGF antagonists suppressed the conversion of pancreatic tumors from carcinoma in situ into invasive cancer [ 23 ] . It seems that regulation of the HGF/SF stimulation and inhibition activities is associated with the metastatic potential of tumor cells, and knowing the status of HGFA, HAI-1 and HAI-2, in addition to Met, might provide useful information.
Normal mammary ducts within infiltrating cancer showed intermediate levels of HGF/SF.
Cells treated with HGF/SF and Adriamycin also had modified cell line regulation and signal transduction that might suggest mechanisms by which HGF/SF exerts its protective activity [ 31 ] .
ER = estrogen receptor; HGFA = hepatocyte growth factor activator; HGF/SF = hepatocyte growth factor/scatter factor; PR = progesterone receptor; RT-PCR = reverse transcriptase-polymerase chain reaction.
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