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Example sentences for: hgec

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HGEN, HGEC and HPT were chosen for examination in this study because these cell types, at least in vitro , have been shown to be injured by Stx-1 [ 6 7 8 ] . Mesangial cells were not examined since Stx-1 has not been demonstrated to affect their viability [ 13 ] . Previous studies have separately examined the cytotoxic effect of Stx-1 on HGEN [ 8 ] , HGEC [ 10 ] , and HPT [ 9 ] , however this is the first study to directly compare Stx-1 sensitivity of these renal cell types.
Primary cultures of HGEC were obtained from nephrectomies as previously described [ 10 ] and studied at the third passage.
Although speculative, it is tempting to propose that HPT and HGEC may be early targets of Stx-1 and that this could play a role in the pathophysiologic processes that characterize renal injury in HUS.
These data indicate that, as suggested from the previous studies, within the limits of the cell culture system, HPT are the most sensitive to Stx-1 cytotoxicity of the three cell types, HGEC are slightly less sensitive, and HGEN are at least three orders of magnitude less sensitive than either HGEC or HPT.
Stx-1 (72 hr exposure to toxin) dose-dependently killed HGEN, HGEC and HPT (Figure 1).