Example sentences for: hdac

How can you use “hdac” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We also found evidence that promoter methylation inactivates gene expression in CC and exposure to methylation and/or histone deacetylase (HDAC)-inhibiting agents reactivate the gene expression.

  • Since ERβ bound N-CoR and SMRT in the presence of estrogens, we investigated the possible involvement of corepressors in the actions of agonist-bound ERβ in vivo . To perform this experiment, we examined the effect of the HDAC inhibitor trichostatin A (TSA) on ERβ activity in transiently transfected HeLa cells.

  • Other reports suggest that Rb recruitment of HDAC1 activity repressed E2F-1 [ 12, 13].

  • HDAC inhibitors, such as trichostatin A and trapoxin, modulate gene expression in either a positive, negative or neutral fashion [ 45].

  • A HDAC Repressor Enhances ERβ Activity


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