Words similar to hdac
Example sentences for: hdac
How can you use “hdac” in a sentence? Here are some example sentences to help you improve your vocabulary:
Since ERβ bound N-CoR and SMRT in the presence of estrogens, we investigated the possible involvement of corepressors in the actions of agonist-bound ERβ in vivo . To perform this experiment, we examined the effect of the HDAC inhibitor trichostatin A (TSA) on ERβ activity in transiently transfected HeLa cells.
A highly ordered chromatin structure presents a physical obstacle for gene transcription; presumably by limiting the access of transcription factors and RNA polymerase II core machinery to target DNA [ 82 83 ] . In concert with the observation that corepressors are associated with HDAC activities [ 84 85 ] , it appears that the transcriptional outcome of nuclear receptors is determined by the balance of histone acetylation and deacetylation activities, and that ligands serve as a switch to recruit HATs with the concomitant dismissal of HDACs.
We also found evidence that promoter methylation inactivates gene expression in CC and exposure to methylation and/or histone deacetylase (HDAC)-inhibiting agents reactivate the gene expression.
HDAC inhibitors, such as trichostatin A and trapoxin, modulate gene expression in either a positive, negative or neutral fashion [ 45].
The resulting retinoblastoma protein (Rb)-E2F interaction not only blocks transcriptional activation by E2F, but also forms an active transcriptional repressor complex at the promoter of cell cycle genes that can block transcription by recruiting histone deacetylase (HDAC) and remodeling chromatin [ 11, 12, 13, 14].
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