Example sentences for: hdac

How can you use “hdac” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Although SAHA increases acetylation of histones H3 and H4, it is not known whether SAHA is able to inhibit all HDAC activities of all types of histones, including HDAC1, or whether the profound increase in Rb2/p130-E2F-4 nuclear complex after SAHA treatment may have an alternative pathway other than recruitment of HDAC1 activity.

  • HDAC inhibitors, such as trichostatin A and trapoxin, modulate gene expression in either a positive, negative or neutral fashion [ 45].

  • HDAC Histone de-acetylase

  • Other reports suggest that Rb recruitment of HDAC1 activity repressed E2F-1 [ 12, 13].

  • We also found evidence that promoter methylation inactivates gene expression in CC and exposure to methylation and/or histone deacetylase (HDAC)-inhibiting agents reactivate the gene expression.


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