Words similar to hcar

Example sentences for: hcar

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In an effort to facilitate gene transfer into primary lymphocytes, we and others [ 14 15 ] have employed different strategies to engineer transgenic mice that express the human adenoviral receptor, hCAR, on murine lymphocytes.
For these experiments, we used line 13 DO11.hCARΔcyt Tg mice that have a bimodal distribution of hCAR expression to provide an internal control, "sham transfection" population.
For this reason, we chose to use a truncated variant of hCAR to preclude possible signaling by this molecule [ 13 ] . As evidenced by the functional data reported herein, and those from previous reports [ 14 15 ] , there does not appear to be an adverse effect of either hCARΔcyt expression or adenoviral transduction on T cell activation, development or function.
Here we report the characterization of three new transgenic lines that express a cytoplasmic-tail truncated hCAR under control of hCD2 gene regulatory elements, and demonstrate their utility for gene transfer studies of primary T cells and thymocytes.
hCAR human coxsackie/adenovirus receptor