Words similar to hcar

Example sentences for: hcar

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An important consideration at the outset of these studies concerned the possibility that ectopic hCAR expression or adenoviral transduction might affect the normal development and/or function of T cells.
The development of newer recombinant adenoviruses containing elements for epichromosomal replication may alleviate limitations that prevent more stable in vivo expression in dividing lymphoid cells derived from hCAR transgenic mice.
This mini-gene includes the 5' promoter region of the hCD2 gene as well as the hCD2 LCR, which is reported to direct transgene expression to T cells in a position-independent, copy number-dependent manner [ 17 18 ] . Since the function of CAR is undefined, and deletion of the cytoplasmic tail of hCAR does not adversely affect adenoviral transduction [ 13 19 ] , a cDNA encoding a cytoplasmic tail-truncated variant of hCAR (hCARΔcyt) was generated and inserted into the CD2 mini-gene to eliminate any potential signaling capacity of hCAR.
Thus, neither hCAR expression nor adenoviral transduction alters the naïve T cell's potential for Th1 or Th2 phenotype development.
In an effort to facilitate gene transfer into primary lymphocytes, we and others [ 14 15 ] have employed different strategies to engineer transgenic mice that express the human adenoviral receptor, hCAR, on murine lymphocytes.