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Example sentences for: hcaf

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The pVP16-hCAF1 and pVP16-hPOP2 constructs were obtained upon insertion of the hCAF1 and hPOP2 coding regions into the pSG5FNV vector, in-frame with the VP16 transactivation domain coding sequence, as previously described [ 17 25 ] .
Indeed, both human homologs of yPOP2, hCAF1 and hPOP2, lack the 148 N-terminal amino acids which are, in yPOP2, required for transcriptional activation, whereas the yPOP2 C-terminus, which is involved in the interaction with yCCR4, is conserved in hCAF1 [ 11 ] and hPOP2 [ 19 ] . Similarly, hNOT2, the human homolog of the yNOT2 component of the CCR4-NOT complex, harbors a N-terminal domain divergent from that of yNOT2 -required for transcriptional activation and interaction with the yeast ADA2 factor-, but has conserved the C-terminal domain which is absolutely required for the yCCR4-associated function of yNOT2 [ 19 20 ] . Therefore, it looks as if genes of the CCR4-NOT complex have undergone a "concerted" phylogenetic evolution, with the yeast genes encoding multifunctional proteins and the animal genes only encoding "specialized" proteins specific for the CCR4-NOT complex.
A vector expressing hCAF1 (pVP16-hCAFl) or hPOP2 (pVP16-hPOP2) fused to the VP16 activation domain was also produced (Fig.
Interestingly, we found that hCCR4 also binds to the second human yPOP2 paralog, hCAF1.
4), thus indicating that m.nocturnin does not interact with hCAF1 or hPOP2, as expected from the absence of an LRR domain in this protein.