Words similar to gpcr

Example sentences for: gpcr

How can you use “gpcr” in a sentence? Here are some example sentences to help you improve your vocabulary:

The 5-HT 2C receptor is a member of the GPCR family.
It has been postulated that activation of these kinases allows GPCR agonists to modulate such diverse molecular events as cell proliferation, differentiation, and survival [ 1 ] . To date, all three cloned opioid receptor types (μ,δ, κ) and the closely related nociceptin receptor have demonstrated the ability to signal through their heterotrimeric G proteins (G i or G o ) to at least one type of MAPK [ 2 3 4 ] . Among the members of this family that are activated by opioids, are the two extracellular signal-regulated protein kinases (p44 MAPK(ERK 1) and p42 MAPK(ERK 2)) [ 5 ] and the p38 protein kinase [ 3 ] . However, the precise mechanism by which OR stimulation produces an increase in MAPK activity is still unknown and under investigation.
‘There is a precedent for that’, he claims, noting that extracellular calcium is sensed by a GPCR.
Furthermore, since some GPCRs can modulate MAP kinase activity, MAP kinase regulation of GPCR function may then serve as a form of negative feedback control in much the same way that protein kinase A, protein kinase C and the G protein-coupled receptor kinases (GRKs) regulate GPCRs.
Two relatively novel concepts for Hh signaling are raised by these GPCR models: firstly, the importance of considering the active Smo-coupler/effector complexes when modeling pathway regulation, and secondly the potential for endogenous ligands in the regulation of Smo activity.