Example sentences for: gpcr

How can you use “gpcr” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To determine the effect of insulin receptor or IGF-1 receptor activation on GPCR's, cells were treated with insulin or IGF-1.

  • To our knowledge, this is the first description of MAP kinase regulation of a GPCR and suggests that this form of regulation may be more wide-spread than has been previously recognized.

  • G protein-coupled receptor (GPCR) kinase-interactor-2 (Fig.

  • Despite numerous reported differences, it does appear that diverse GPCRs share common mechanistic themes during ERK stimulation, including the tyrosine-phosphorylation of Shc and its complexing with Grb2, mSOS recruitment, the GTP-loading of Ras, and Raf-1 activation leading to MEK-1 phosphorylation [ 1 ] . However, the progression of each of these downstream events after GPCR stimulation depends first on the tyrosine phosphorylation of a membrane-bound protein that will be used as a scaffold, which will bind the other proteins (e.g.

  • Two possibilities have emerged as potential sites of tyrosine phosphorylation and subsequent scaffold building in response to GPCR stimulation, which results in ERK activation: the GPCR, itself, or a co-expressed RTK (i.e.


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