Words similar to gpc
Example sentences for: gpc
How can you use “gpc” in a sentence? Here are some example sentences to help you improve your vocabulary:
The first two exons of the GPC5 gene are present in BAC clone accession number AL138714, exons 3,4,5 in AC027429, exon 6 in AL162456, exon 7 in AL163537 and exon 8 in AL157363 (Table 2).
Deletion of the 13q region is associated with human 13q syndrome, a developmental disorder [ 24 ] . Some of the proteoglycans play important functional roles in neurogenesis, axon guidance, synapse development [ 25 ] , and cellular growth and differentiation [ 26 27 23 ] . Mutations in GPC3 cause Simpson-Golabi-Behmel syndrome [ 28 29 ] , however, no mutations were detected in the GPC5 and GPC6 genes [ 30 ] . The glypican1 gene has been suggested to be a good candidate for brachydactyly type E [ 31 ] . Given that, GPC5 is highly expressed in brain and mutations in other genes of the glypican families are associated with developmental disorder; GPC5 could be a potential candidate gene for Bipolar disorder.
Intronic oligonucleotide primer pairs flanking the coding fragments were designed for both the genes using program primer 3 http://www.genome.wi.mit.edu/cgi-bin/primer/primer3.cgiusing the genomic sequences of SLC15A1 and GPC5 gene respectively.
Absence of pathogenic mutations in the two genes GPC5 and SLC15A1 studied in seven families of Bipolar disorder suggests that these genes are presumably not involved in the susceptibility locus for Bipolar disorder in the families screened.
An association study of the variants detected in GPC5 and SLC15A1 genes in a large gene population will aid in understanding the potential role of these genes in Bipolar disorders.
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