Words similar to gpc
Example sentences for: gpc
How can you use “gpc” in a sentence? Here are some example sentences to help you improve your vocabulary:
Deletion of the 13q region is associated with human 13q syndrome, a developmental disorder [ 24 ] . Some of the proteoglycans play important functional roles in neurogenesis, axon guidance, synapse development [ 25 ] , and cellular growth and differentiation [ 26 27 23 ] . Mutations in GPC3 cause Simpson-Golabi-Behmel syndrome [ 28 29 ] , however, no mutations were detected in the GPC5 and GPC6 genes [ 30 ] . The glypican1 gene has been suggested to be a good candidate for brachydactyly type E [ 31 ] . Given that, GPC5 is highly expressed in brain and mutations in other genes of the glypican families are associated with developmental disorder; GPC5 could be a potential candidate gene for Bipolar disorder.
Each sample was analyzed for exon 2-23 of the SLC15A1 gene (Table 3) and 7 coding fragments of the GPC5 gene (Table 4).
The genomic structures of SLC15A1 (accession number U21936) and GPC5 (accession number U66033) were determined by direct comparison of their full-length cDNA with the sequence of human chromosome 13 genomic clones retrieved from the GenBank htgs database http://www.ncbi.nlm.nih.gov/by BLASTN searching.
While we finished screening this gene for mutations, its genomic structure was published and confirms the presence of 8 exons with exon/intron boundaries following the AG/GT rule with a size of approximately 2 Mb [ 30 ] . No mutations or polymorphisms were identified in the GPC5 gene in the 7 families affected with Bipolar disorder decreasing the likelihood that this gene is involved in the etiology of Bipolar disorder.
Exon 3 of GPC 5 was sequenced with ABI Big Dye terminator chemistry.
Loading...