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Example sentences for: gpcrs

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In addition to the binding sites for natural or endogenous agonists (orthosteric sites), many GPCRs have also been found to have allosteric sites [ 35 ] . These sites can bind natural ligands, as in the case of Zn ions and heparin for the dopamine and neurokinin receptors, respectively, or bind synthetic drugs such gallamine, in the case of the muscarinic receptors [ 35 ] . Binding of small molecules to these allosteric sites can modulate activity of a receptor without directly mimicking or competing out the interaction of ligands to the orthosteric sites.
And, he says, GPCRs could also be involved in these modalities.
EGFR, IR, or PDGFR) stimulate ERKs [ 22 23 ] , no single sequence of events appears to hold among GPCRs, even when they are expressed in the same cell line.
Thus we introduce a ternary complex model (Figure 8b), used traditionally to describe the behavior of GPCRs in binding studies with agonist and antagonists [ 31 ] , as well as constitutively active receptors [ 29 ] . The ternary complex model for Hh signaling suggests that there are two independent binding sites on Smo wt, one specific for the agonist and another specific for antagonists.
The sweet receptor story started in 1999 with the identification of two putative mammalian taste receptors, GPCRs now known as T1R1 and T1R2.