Example sentences for: gpcrs

How can you use “gpcrs” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • And, he says, GPCRs could also be involved in these modalities.

  • Thus we introduce a ternary complex model (Figure 8b), used traditionally to describe the behavior of GPCRs in binding studies with agonist and antagonists [ 31 ] , as well as constitutively active receptors [ 29 ] . The ternary complex model for Hh signaling suggests that there are two independent binding sites on Smo wt, one specific for the agonist and another specific for antagonists.

  • These data suggest that the tyrosine phosphorylation of GPCRs may allow them to signal ERKs in the absence of RTK or FAK phosphorylation by acting as their own scaffolds.

  • Second, the extreme C-termini of Gα are critical sites for interaction with GPCRs [ 32 ] , and the novel C-terminal sequence found in sα i2 would be predicted to disrupt productive interactions with GPCRs.

  • With the first evidence that GPCRs could signal via the MAPK cascade, many investigators have looked for a common mechanism of activation that could be applied across receptor types.


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